Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

Yifan Li; Mélanie Merbah; Suzanne Wollen-Roberts; Bradley Beckman; Thembi Mdluli; Isabella Swafford; Sandra V. Mayer; Jocelyn King; Courtney Corbitt; Jeffrey R. Currier; Heather Liu; Allahna Esber; Suteeraporn Pinyakorn; Ajay Parikh; Leilani V. Francisco; Nittaya Phanuphak; Jonah Maswai; John Owuoth; Hannah Kibuuka; Michael Iroezindu; Emmanuel Bahemana; Sandhya Vasan; Julie A. Ake; Kayvon Modjarrad; Gregory Gromowski; Dominic Paquin-Proulx; Morgane Rolland

doi:10.3201/eid2811.221041

Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

Yifan Li, Mélanie Merbah, Suzanne Wollen-Roberts, Bradley Beckman, Thembi Mdluli, Isabella Swafford, Sandra V. Mayer, Jocelyn King, Courtney Corbitt, Jeffrey R. Currier, Heather Liu, Allahna Esber, Suteeraporn Pinyakorn, Ajay Parikh, Leilani V. Francisco, Nittaya Phanuphak, Jonah Maswai, John Owuoth, Hannah Kibuuka, Michael IroezinduEmmanuel Bahemana, Sandhya Vasan, Julie A. Ake, Kayvon Modjarrad, Gregory Gromowski, Dominic Paquin-Proulx, Morgane Rolland^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya, Nigeria, Tanzania, and Uganda) and in Thailand, including persons living with HIV-1. We detected IgG responses to SARS-CoV-2 spike (S) subunit 2 protein in 1.8% of participants. Profiling against 23 coronavirus antigens revealed that responses to S, subunit 2, or subunit 1 proteins were significantly more frequent than responses to the receptor-binding domain, S-Trimer, or nucleocapsid proteins (p<0.0001). We observed similar responses in persons with or without HIV-1. Among all coronavirus antigens tested, SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome coronavirus antibody responses were much higher in participants from Africa than in participants from Thailand (p<0.01). We noted less pronounced differences for endemic coronaviruses. Serosurveys could affect vaccine and monoclonal antibody distribution across global populations.

Original language	English
Pages (from-to)	2214-2225
Number of pages	12
Journal	Emerging Infectious Diseases
Volume	28
Issue number	11
DOIs	https://doi.org/10.3201/eid2811.221041
State	Published - Nov 2022
Externally published	Yes

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Li, Y., Merbah, M., Wollen-Roberts, S., Beckman, B., Mdluli, T., Swafford, I., Mayer, S. V., King, J., Corbitt, C., Currier, J. R., Liu, H., Esber, A., Pinyakorn, S., Parikh, A., Francisco, L. V., Phanuphak, N., Maswai, J., Owuoth, J., Kibuuka, H., ... Rolland, M. (2022). Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand. Emerging Infectious Diseases, 28(11), 2214-2225. https://doi.org/10.3201/eid2811.221041

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title = "Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand",

abstract = "Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya, Nigeria, Tanzania, and Uganda) and in Thailand, including persons living with HIV-1. We detected IgG responses to SARS-CoV-2 spike (S) subunit 2 protein in 1.8% of participants. Profiling against 23 coronavirus antigens revealed that responses to S, subunit 2, or subunit 1 proteins were significantly more frequent than responses to the receptor-binding domain, S-Trimer, or nucleocapsid proteins (p<0.0001). We observed similar responses in persons with or without HIV-1. Among all coronavirus antigens tested, SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome coronavirus antibody responses were much higher in participants from Africa than in participants from Thailand (p<0.01). We noted less pronounced differences for endemic coronaviruses. Serosurveys could affect vaccine and monoclonal antibody distribution across global populations.",

author = "Yifan Li and M{\'e}lanie Merbah and Suzanne Wollen-Roberts and Bradley Beckman and Thembi Mdluli and Isabella Swafford and Mayer, {Sandra V.} and Jocelyn King and Courtney Corbitt and Currier, {Jeffrey R.} and Heather Liu and Allahna Esber and Suteeraporn Pinyakorn and Ajay Parikh and Francisco, {Leilani V.} and Nittaya Phanuphak and Jonah Maswai and John Owuoth and Hannah Kibuuka and Michael Iroezindu and Emmanuel Bahemana and Sandhya Vasan and Ake, {Julie A.} and Kayvon Modjarrad and Gregory Gromowski and Dominic Paquin-Proulx and Morgane Rolland",

year = "2022",

month = nov,

doi = "10.3201/eid2811.221041",

language = "English",

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Li, Y, Merbah, M, Wollen-Roberts, S, Beckman, B, Mdluli, T, Swafford, I, Mayer, SV, King, J, Corbitt, C, Currier, JR, Liu, H, Esber, A, Pinyakorn, S, Parikh, A, Francisco, LV, Phanuphak, N, Maswai, J, Owuoth, J, Kibuuka, H, Iroezindu, M, Bahemana, E, Vasan, S, Ake, JA, Modjarrad, K, Gromowski, G, Paquin-Proulx, D & Rolland, M 2022, 'Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand', Emerging Infectious Diseases, vol. 28, no. 11, pp. 2214-2225. https://doi.org/10.3201/eid2811.221041

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T1 - Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

AU - Li, Yifan

AU - Merbah, Mélanie

AU - Wollen-Roberts, Suzanne

AU - Beckman, Bradley

AU - Mdluli, Thembi

AU - Swafford, Isabella

AU - Mayer, Sandra V.

AU - King, Jocelyn

AU - Corbitt, Courtney

AU - Currier, Jeffrey R.

AU - Liu, Heather

AU - Esber, Allahna

AU - Pinyakorn, Suteeraporn

AU - Parikh, Ajay

AU - Francisco, Leilani V.

AU - Phanuphak, Nittaya

AU - Maswai, Jonah

AU - Owuoth, John

AU - Kibuuka, Hannah

AU - Iroezindu, Michael

AU - Bahemana, Emmanuel

AU - Vasan, Sandhya

AU - Ake, Julie A.

AU - Modjarrad, Kayvon

AU - Gromowski, Gregory

AU - Paquin-Proulx, Dominic

AU - Rolland, Morgane

PY - 2022/11

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N2 - Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya, Nigeria, Tanzania, and Uganda) and in Thailand, including persons living with HIV-1. We detected IgG responses to SARS-CoV-2 spike (S) subunit 2 protein in 1.8% of participants. Profiling against 23 coronavirus antigens revealed that responses to S, subunit 2, or subunit 1 proteins were significantly more frequent than responses to the receptor-binding domain, S-Trimer, or nucleocapsid proteins (p<0.0001). We observed similar responses in persons with or without HIV-1. Among all coronavirus antigens tested, SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome coronavirus antibody responses were much higher in participants from Africa than in participants from Thailand (p<0.01). We noted less pronounced differences for endemic coronaviruses. Serosurveys could affect vaccine and monoclonal antibody distribution across global populations.

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DO - 10.3201/eid2811.221041

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JO - Emerging Infectious Diseases

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ER -

Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand

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