TY - JOUR
T1 - Coronavirus Antibody Responses before COVID-19 Pandemic, Africa and Thailand
AU - Li, Yifan
AU - Merbah, Mélanie
AU - Wollen-Roberts, Suzanne
AU - Beckman, Bradley
AU - Mdluli, Thembi
AU - Swafford, Isabella
AU - Mayer, Sandra V.
AU - King, Jocelyn
AU - Corbitt, Courtney
AU - Currier, Jeffrey R.
AU - Liu, Heather
AU - Esber, Allahna
AU - Pinyakorn, Suteeraporn
AU - Parikh, Ajay
AU - Francisco, Leilani V.
AU - Phanuphak, Nittaya
AU - Maswai, Jonah
AU - Owuoth, John
AU - Kibuuka, Hannah
AU - Iroezindu, Michael
AU - Bahemana, Emmanuel
AU - Vasan, Sandhya
AU - Ake, Julie A.
AU - Modjarrad, Kayvon
AU - Gromowski, Gregory
AU - Paquin-Proulx, Dominic
AU - Rolland, Morgane
N1 - Publisher Copyright:
© 2022 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2022/11
Y1 - 2022/11
N2 - Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya, Nigeria, Tanzania, and Uganda) and in Thailand, including persons living with HIV-1. We detected IgG responses to SARS-CoV-2 spike (S) subunit 2 protein in 1.8% of participants. Profiling against 23 coronavirus antigens revealed that responses to S, subunit 2, or subunit 1 proteins were significantly more frequent than responses to the receptor-binding domain, S-Trimer, or nucleocapsid proteins (p<0.0001). We observed similar responses in persons with or without HIV-1. Among all coronavirus antigens tested, SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome coronavirus antibody responses were much higher in participants from Africa than in participants from Thailand (p<0.01). We noted less pronounced differences for endemic coronaviruses. Serosurveys could affect vaccine and monoclonal antibody distribution across global populations.
AB - Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya, Nigeria, Tanzania, and Uganda) and in Thailand, including persons living with HIV-1. We detected IgG responses to SARS-CoV-2 spike (S) subunit 2 protein in 1.8% of participants. Profiling against 23 coronavirus antigens revealed that responses to S, subunit 2, or subunit 1 proteins were significantly more frequent than responses to the receptor-binding domain, S-Trimer, or nucleocapsid proteins (p<0.0001). We observed similar responses in persons with or without HIV-1. Among all coronavirus antigens tested, SARS-CoV-2, SARS-CoV-1, and Middle East respiratory syndrome coronavirus antibody responses were much higher in participants from Africa than in participants from Thailand (p<0.01). We noted less pronounced differences for endemic coronaviruses. Serosurveys could affect vaccine and monoclonal antibody distribution across global populations.
UR - https://www.scopus.com/pages/publications/85140855226
U2 - 10.3201/eid2811.221041
DO - 10.3201/eid2811.221041
M3 - Article
C2 - 36220131
AN - SCOPUS:85140855226
SN - 1080-6040
VL - 28
SP - 2214
EP - 2225
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 11
ER -