Coronavirus-induced demyelination and spontaneous remyelination growth factor expression and function

Regina C. Armstrong; Jeffrey M. Redwine; Donna J. Messersmith

doi:10.1007/0-387-25518-4_44

Coronavirus-induced demyelination and spontaneous remyelination growth factor expression and function

Regina C. Armstrong^*
, Jeffrey M. Redwine
, Donna J. Messersmith

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

MHV-A59 coronavirus infection produces a transient episode of demyelination that is followed by spontaneous remyelination. This paradigm provides a complex lesion environment to examine cellular and molecular mechanisms involved in successful CNS remyelination. Our work in this model has focused on the roles of platelet-derived growth factor and fibroblast growth factor 2 in regulating oligodendrocyte progenitor responses required for remyelination.

Original language	English
Title of host publication	Experimental Models of Multiple Sclerosis
Publisher	Springer US
Pages	793-803
Number of pages	11
ISBN (Electronic)	9780387255187
ISBN (Print)	0387255176, 9780387255170
DOIs	https://doi.org/10.1007/0-387-25518-4_44
State	Published - 2005

Keywords

coronavirus
cuprizone
demyelinating disease
estrous cycle
fibroblast growth factor
gender
platelet-derived growth factor
remyelination

Access to Document

10.1007/0-387-25518-4_44

Cite this

@inbook{837ff2b0c5034a088cdffb26479e6e41,

title = "Coronavirus-induced demyelination and spontaneous remyelination growth factor expression and function",

abstract = "MHV-A59 coronavirus infection produces a transient episode of demyelination that is followed by spontaneous remyelination. This paradigm provides a complex lesion environment to examine cellular and molecular mechanisms involved in successful CNS remyelination. Our work in this model has focused on the roles of platelet-derived growth factor and fibroblast growth factor 2 in regulating oligodendrocyte progenitor responses required for remyelination.",

keywords = "coronavirus, cuprizone, demyelinating disease, estrous cycle, fibroblast growth factor, gender, platelet-derived growth factor, remyelination",

author = "Armstrong, \{Regina C.\} and Redwine, \{Jeffrey M.\} and Messersmith, \{Donna J.\}",

year = "2005",

doi = "10.1007/0-387-25518-4\_44",

language = "English",

isbn = "0387255176",

pages = "793--803",

booktitle = "Experimental Models of Multiple Sclerosis",

publisher = "Springer US",

}

TY - CHAP

T1 - Coronavirus-induced demyelination and spontaneous remyelination growth factor expression and function

AU - Armstrong, Regina C.

AU - Redwine, Jeffrey M.

AU - Messersmith, Donna J.

PY - 2005

Y1 - 2005

N2 - MHV-A59 coronavirus infection produces a transient episode of demyelination that is followed by spontaneous remyelination. This paradigm provides a complex lesion environment to examine cellular and molecular mechanisms involved in successful CNS remyelination. Our work in this model has focused on the roles of platelet-derived growth factor and fibroblast growth factor 2 in regulating oligodendrocyte progenitor responses required for remyelination.

AB - MHV-A59 coronavirus infection produces a transient episode of demyelination that is followed by spontaneous remyelination. This paradigm provides a complex lesion environment to examine cellular and molecular mechanisms involved in successful CNS remyelination. Our work in this model has focused on the roles of platelet-derived growth factor and fibroblast growth factor 2 in regulating oligodendrocyte progenitor responses required for remyelination.

KW - coronavirus

KW - cuprizone

KW - demyelinating disease

KW - estrous cycle

KW - fibroblast growth factor

KW - gender

KW - platelet-derived growth factor

KW - remyelination

UR - https://www.scopus.com/pages/publications/33646768788

U2 - 10.1007/0-387-25518-4_44

DO - 10.1007/0-387-25518-4_44

M3 - Chapter

AN - SCOPUS:33646768788

SN - 0387255176

SN - 9780387255170

SP - 793

EP - 803

BT - Experimental Models of Multiple Sclerosis

PB - Springer US

ER -

Coronavirus-induced demyelination and spontaneous remyelination growth factor expression and function

Abstract

Keywords

Access to Document

Fingerprint

Cite this