@article{da362321df714a3f8d5028f4956b6a11,
title = "Cortisol response to an induction of negative affect among adolescents with and without loss of control eating",
abstract = "Background: Adults with binge eating disorder may have an exaggerated or blunted cortisol response to stress. Yet, limited data exist among youth who report loss of control (LOC) eating, a developmental precursor to binge eating disorder. Methods: We studied cortisol reactivity among 178 healthy adolescents with and without LOC eating. Following a buffet lunch meal adolescents were randomly assigned to watch a neutral or sad film clip. After, they were offered snacks from a multi-item array to assess eating in the absence of hunger. Salivary cortisol was collected at −80, 0, 30 and 50 min relative to film administration, and state mood ratings were reported before and after the film. Results: Adolescents with LOC had greater increases in negative affect during the experimental paradigm in both conditions (ps > 0.05). Depressive symptoms, but not LOC, related to a greater cortisol response in the sad film condition (ps > 0.05). Depressive symptoms and state LOC were related to different aspects of eating behaviour, independent of film condition or cortisol response (ps > 0.05). Conclusions: A film clip that induced depressed state affect increased salivary cortisol only in adolescents with more elevated depressive symptoms. Adolescents with and without LOC were differentiated by greater increases in state depressed affect during laboratory test meals but had no difference in cortisol reactivity. Future studies are required to determine if adolescents with LOC manifest alterations in stress reactivity to alternative stress-inducing situations.",
keywords = "adolescence, binge eating, cortisol, depressive symptoms, loss of control eating",
author = "Radin, {R. M.} and Shomaker, {L. B.} and Kelly, {N. R.} and Pickworth, {C. K.} and Thompson, {K. A.} and Brady, {S. M.} and A. Demidowich and O. Galescu and Altschul, {A. M.} and Shank, {L. M.} and Yanovski, {S. Z.} and M. Tanofsky-Kraff and Yanovski, {J. A.}",
note = "Funding Information: R.M.R., L.B.S., M.T.K. and J.A.Y. conceived the hypothesis for this article. R.M.R., L.B.S., M.T.K. and J.A.Y. wrote the first draft of the manuscript. R.M.R., M.T.K., L.B.S. and J.A.Y. conducted data analysis. All authors (R.M.R., M.T.K., L.B.S., N.R.K., C.K.P., K.A.T., S.M.B., A.D., O.G., A.A., L.M.S., S.Z.Y. and J.A.Y.) participated in data collection, reviewed and edited the manuscript and approved the final version of the manuscript. J. Yanovski is a commissioned officer in the US Public Health Service (PHS).Funding for this study was provided by the following sources: NIH National Research Service Award F32HD056762 and Pathway to Independence Award K99/R00HD069516 (L. Shomaker) from NICHD; NIH Intramural Research Program Grant 1ZIAHD000641 (J. Yanovski) from NICHD with supplemental funding from the NIH Bench to Bedside Program and the Office of Behavioral and Social Sciences Research. The aforementioned funding source (NICHD) had no role in the study design, collection, analysis or interpretation of data, writing of the manuscript or decision to submit the paper for publication. The opinions and assertions expressed herein are those of the authors and are not to be construed as reflecting the views of the PHS, USUHS or the US Department of Defense. Portions of this study were presented at The Obesity Society, Boston, MA, November, 2014. Publisher Copyright: {\textcopyright} 2015 World Obesity Federation",
year = "2016",
month = dec,
day = "1",
doi = "10.1111/ijpo.12095",
language = "English",
volume = "11",
pages = "513--520",
journal = "Pediatric Obesity",
issn = "2047-6302",
number = "6",
}