Covalent binding to tubulin by isothiocyanates: A mechanism of cell growth arrest and apoptosis

Medicine & Life Sciences

• Isothiocyanates 100%
• Tubulin 68%
• Apoptosis 38%
• Growth 32%
• sulforafan 30%
• A549 Cells 11%
• benzyl isothiocyanate 9%
• phenethyl isothiocyanate 8%
• Electrophoresis, Gel, Two-Dimensional 6%
• Polymerization 5%
• Vegetables 5%
• Microtubules 5%
• Cell Cycle Checkpoints 5%
• Cysteine 5%
• Mass Spectrometry 4%
• Lung Neoplasms 4%
• Carcinogenesis 4%
• Proteins 3%
• Animal Models 3%
• In Vitro Techniques 2%

Chemistry

• Isothiocyanate 71%
• Sulforaphane 42%
• Cell Growth Inhibition 18%
• Phenethyl Isothiocyanate 11%
• Benzyl Isothiocyanate 10%
• Growth Inhibition 7%
• Two Dimensional Polyacrylamide Gel Electrophoresis 7%
• Cysteine 5%
• Protein 5%
• Adduct 4%
• Mass Spectrometry 4%
• Polymerization Reaction 3%
• Modification 3%