Cranial suture biology: From pathways to patient care

Benjamin Levi, Derrick C. Wan, Victor W. Wong, Emily Nelson, Jeong Hyun, Michael T. Longaker*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Craniosynostosis describes the premature pathologic partial or complete fusion of 1 or more of the cranial sutures. Over the past few decades, research on craniosynostosis has progressed from gross description of deformities to an understanding of some of the molecular etiologies behind premature suture fusion. Studies on patients with syndromic craniosynostosis have resulted in the identification of several genes, molecular events, and deformational forces involved in abnormal growth and development of the cranial vault. Conservation of craniofacial development and sequence homology between humans and other species have also led to insightful discoveries in cranial suture development. In this review, we discuss the development of the cranial vault and explain the basic science behind craniosynostosis in humans as well as in animal models and how these studies may lead to future advances in craniosynostosis treatments.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalJournal of Craniofacial Surgery
Issue number1
StatePublished - Jan 2012
Externally publishedYes


  • Cranial suture development
  • Cranial vault
  • Craniosynostosis
  • Dura mater
  • Fibroblast growth factor
  • Suture mesenchymal cells


Dive into the research topics of 'Cranial suture biology: From pathways to patient care'. Together they form a unique fingerprint.

Cite this