Creatine reduces 3-nitropropionic-acid-induced cognitive and motor abnormalities in rats

Deborah A. Shear, Kristi L. Haik, Gary L. Dunbar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


This study assessed whether creatine could attenuate 3-nitropropionic acid (3NP)-induced neuropathological and behavioral abnormalities that are analogous to those observed in Huntington's disease (HD). Rats were fed diets containing either 1% creatine or normal rat chow for 2 weeks prior to the onset of 3NP administration, and for the duration of the study. 3NP was administered systemically in gradually increasing concentrations over an 8- week testing period. Results show that creatine can attenuate 3NP-induced striatal lesions, striatal atrophy, ventricular enlargement, cognitive deficits, and motor abnormalities on a balance beam task. Collectively, these findings indicate that creatine provides significant protection against 3NP- induced behavioral and neuropathological abnormalities and may have therapeutic potential for HD. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)1833-1837
Number of pages5
Issue number9
StatePublished - 26 Jun 2000
Externally publishedYes


  • 3-Nitropropionic acid
  • Creatine
  • Cytochrome oxidase
  • Huntington's disease
  • Radial arm water maze
  • Reference memory
  • Spatial learning
  • Working memory


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