Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy

Sohail Rao; Monica Betancourt-Garcia; Yetunde O. Kare-Opaneye; Brett E. Swierczewski; Jason W. Bennett; Bri'Anna Horne; Joseph Fackler; Lia Patricia Suazo Hernandez; Michael J. Brownstein

doi:10.1128/AAC.00824-21

Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy

Sohail Rao^*
, Monica Betancourt-Garcia
, Yetunde O. Kare-Opaneye
, Brett E. Swierczewski
, Jason W. Bennett
, Bri'Anna Horne
, Joseph Fackler
, Lia Patricia Suazo Hernandez
, Michael J. Brownstein^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Hospitalized patients are at risk of developing serious multidrug resistant bacterial infections. This risk is heightened in patients who are on mechanical ventilation, are immunocompromised, and/or have chronic comorbidities. We report the case of a 52-year-old critically ill patient with a multidrug resistant Acinetobacter baumannii (MDR-A) respiratory infection who was successfully treated with antibiotics and intravenous and nebulized bacteriophage therapy.

Original language	English
Article number	e00824-21
Journal	Antimicrobial Agents and Chemotherapy
Volume	66
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00824-21
State	Published - Jan 2022
Externally published	Yes

Keywords

Acinetobacter
Acinetobacter baumannii
Bacteriophage
Bacteriophage therapy
Mechanical ventilation
Multidrug resistance
Multidrug-resistant bacterial infection

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10.1128/AAC.00824-21

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Rao, S., Betancourt-Garcia, M., Kare-Opaneye, Y. O., Swierczewski, B. E., Bennett, J. W., Horne, BA., Fackler, J., Hernandez, L. P. S., & Brownstein, M. J. (2022). Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy. Antimicrobial Agents and Chemotherapy, 66(1), Article e00824-21. https://doi.org/10.1128/AAC.00824-21

@article{a3fbc0a37aff44ecb39e84b1fc9737d7,

title = "Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy",

abstract = "Hospitalized patients are at risk of developing serious multidrug resistant bacterial infections. This risk is heightened in patients who are on mechanical ventilation, are immunocompromised, and/or have chronic comorbidities. We report the case of a 52-year-old critically ill patient with a multidrug resistant Acinetobacter baumannii (MDR-A) respiratory infection who was successfully treated with antibiotics and intravenous and nebulized bacteriophage therapy.",

keywords = "Acinetobacter, Acinetobacter baumannii, Bacteriophage, Bacteriophage therapy, Mechanical ventilation, Multidrug resistance, Multidrug-resistant bacterial infection",

author = "Sohail Rao and Monica Betancourt-Garcia and Kare-Opaneye, \{Yetunde O.\} and Swierczewski, \{Brett E.\} and Bennett, \{Jason W.\} and Bri'Anna Horne and Joseph Fackler and Hernandez, \{Lia Patricia Suazo\} and Brownstein, \{Michael J.\}",

note = "Publisher Copyright: {\textcopyright} 2022 American Society for Microbiology.",

year = "2022",

month = jan,

doi = "10.1128/AAC.00824-21",

language = "English",

volume = "66",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "1",

}

Rao, S, Betancourt-Garcia, M, Kare-Opaneye, YO, Swierczewski, BE, Bennett, JW, Horne, BA, Fackler, J, Hernandez, LPS & Brownstein, MJ 2022, 'Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy', Antimicrobial Agents and Chemotherapy, vol. 66, no. 1, e00824-21. https://doi.org/10.1128/AAC.00824-21

Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy. / Rao, Sohail; Betancourt-Garcia, Monica; Kare-Opaneye, Yetunde O. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 66, No. 1, e00824-21, 01.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy

AU - Rao, Sohail

AU - Betancourt-Garcia, Monica

AU - Kare-Opaneye, Yetunde O.

AU - Swierczewski, Brett E.

AU - Bennett, Jason W.

AU - Horne, Bri'Anna

AU - Fackler, Joseph

AU - Hernandez, Lia Patricia Suazo

AU - Brownstein, Michael J.

PY - 2022/1

Y1 - 2022/1

N2 - Hospitalized patients are at risk of developing serious multidrug resistant bacterial infections. This risk is heightened in patients who are on mechanical ventilation, are immunocompromised, and/or have chronic comorbidities. We report the case of a 52-year-old critically ill patient with a multidrug resistant Acinetobacter baumannii (MDR-A) respiratory infection who was successfully treated with antibiotics and intravenous and nebulized bacteriophage therapy.

AB - Hospitalized patients are at risk of developing serious multidrug resistant bacterial infections. This risk is heightened in patients who are on mechanical ventilation, are immunocompromised, and/or have chronic comorbidities. We report the case of a 52-year-old critically ill patient with a multidrug resistant Acinetobacter baumannii (MDR-A) respiratory infection who was successfully treated with antibiotics and intravenous and nebulized bacteriophage therapy.

KW - Acinetobacter

KW - Acinetobacter baumannii

KW - Bacteriophage

KW - Bacteriophage therapy

KW - Mechanical ventilation

KW - Multidrug resistance

KW - Multidrug-resistant bacterial infection

UR - https://www.scopus.com/pages/publications/85123115611

U2 - 10.1128/AAC.00824-21

DO - 10.1128/AAC.00824-21

M3 - Article

C2 - 34662188

AN - SCOPUS:85123115611

SN - 0066-4804

VL - 66

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

M1 - e00824-21

ER -

Critically Ill Patient with Multidrug-Resistant Acinetobacter baumannii Respiratory Infection Successfully Treated with Intravenous and Nebulized Bacteriophage Therapy

Abstract

Keywords

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