Cross-serotype neutralization of dengue virus in Aotus nancymae monkeys

Tadeusz J. Kochel*, Douglas M. Watts, Alfonso S. Gozalo, Daniel F. Ewing, Kevin R. Porter, Kevin L. Russell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Previously, we observed that serum from humans immune to dengue serotype 1 (dengue-1) neutralized the American genotype of dengue serotype 2 (American-2) to a greater extent than it neutralized the Asian genotype of dengue serotype 2 (Asian-2). To determine if this activity is protective, Aotus nancymae monkeys were infected with dengue-1 followed by either American-2 or Asian-2. Dengue- 1-infected animals produced antibody with neutralizing titers of 2656 antibodies against dengue-1, 409 against American-2, and <20 against Asian-2. Infection with American-2 did not produce detectable viremia in either dengue- 1-immune or dengue-1-naive animals. These findings support the hypothesis that dengue-1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue-1 and American-2.

Original languageEnglish
Pages (from-to)1000-1004
Number of pages5
JournalJournal of Infectious Diseases
Issue number6
StatePublished - 15 Mar 2005
Externally publishedYes


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