TY - JOUR
T1 - Cross-serotype neutralization of dengue virus in Aotus nancymae monkeys
AU - Kochel, Tadeusz J.
AU - Watts, Douglas M.
AU - Gozalo, Alfonso S.
AU - Ewing, Daniel F.
AU - Porter, Kevin R.
AU - Russell, Kevin L.
N1 - Funding Information:
Received 15 April 2004; accepted 31 August 2004; electronically published 31 January 2005. Financial support: US Naval Medical Research Center (work unit 3002A 975 S B0202). Presented in part: 52nd annual meeting of the American Society of Tropical Medicine and Hygiene, Philadelphia, Pennsylvania, 3–7 December 2003 (abstract 373). a Present affiliations: US Naval Medical Research Center, Silver Spring, Maryland (T.J.K.); University of Texas Medical Branch, Galveston (D.M.W.); University of California, Los Angeles (A.S.G.); Naval Health Research Center, Department of Defense Center for Deployment Health Research, San Diego, California (K.L.R.). Reprints or correspondence: Tadeusz J. Kochel, Naval Medical Research Center, 503 Robert Grant Ave., Silver Spring, MD 20910-7500 ([email protected]).
PY - 2005/3/15
Y1 - 2005/3/15
N2 - Previously, we observed that serum from humans immune to dengue serotype 1 (dengue-1) neutralized the American genotype of dengue serotype 2 (American-2) to a greater extent than it neutralized the Asian genotype of dengue serotype 2 (Asian-2). To determine if this activity is protective, Aotus nancymae monkeys were infected with dengue-1 followed by either American-2 or Asian-2. Dengue- 1-infected animals produced antibody with neutralizing titers of 2656 antibodies against dengue-1, 409 against American-2, and <20 against Asian-2. Infection with American-2 did not produce detectable viremia in either dengue- 1-immune or dengue-1-naive animals. These findings support the hypothesis that dengue-1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue-1 and American-2.
AB - Previously, we observed that serum from humans immune to dengue serotype 1 (dengue-1) neutralized the American genotype of dengue serotype 2 (American-2) to a greater extent than it neutralized the Asian genotype of dengue serotype 2 (Asian-2). To determine if this activity is protective, Aotus nancymae monkeys were infected with dengue-1 followed by either American-2 or Asian-2. Dengue- 1-infected animals produced antibody with neutralizing titers of 2656 antibodies against dengue-1, 409 against American-2, and <20 against Asian-2. Infection with American-2 did not produce detectable viremia in either dengue- 1-immune or dengue-1-naive animals. These findings support the hypothesis that dengue-1 immunity might have prevented disease or altered the severity of disease in individuals sequentially infected with dengue-1 and American-2.
UR - http://www.scopus.com/inward/record.url?scp=14844290217&partnerID=8YFLogxK
U2 - 10.1086/427511
DO - 10.1086/427511
M3 - Article
C2 - 15717278
AN - SCOPUS:14844290217
SN - 0022-1899
VL - 191
SP - 1000
EP - 1004
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -