CSF proteome: A protein repository for potential biomarker identification

Martin J. Romeo*, Virginia Espina, Mark Lowenthal, Benjamin H. Espina, Emanuel F. Petricoin, Lance A. Liotta

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Proteomic analysis is not limited to the analysis of serum or tissues. Synovial, peritoneal, pericardial and cerebrospinal fluid represent unique proteomes for disease diagnosis and prognosis. In particular, cerebrospinal fluid serves as a rich source of putative biomarkers that are not solely limited to neurologic disorders. Peptides, proteolytic fragments and antibodies are capable of crossing the blood-brain barrier, thus providing a repository of pathologic information. Proteomic technologies such as immunoblotting, isoelectric focusing, 2D gel electrophoresis and mass spectrometry have proven useful for deciphering this unique proteome. Cerebrospinal fluid proteins are generally less abundant than their corresponding serum counterparts, necessitating the development and use of sensitive analytical techniques. This review highlights some of the promising areas of cerebrospinal fluid proteomic research and their clinical applications.

Original languageEnglish
Pages (from-to)57-70
Number of pages14
JournalExpert Review of Proteomics
Issue number1
StatePublished - Feb 2005
Externally publishedYes


  • 2D gel electrophoresis
  • Biomarker
  • Central nervous system
  • Cerebrospinal fluid
  • Immunoblotting
  • Isoelectric focusing
  • Mass spectrometry
  • Neurodegenerative
  • Protein
  • Proteomics


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