Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

Alok Mishra; Rakesh Kumar; Abhishek Tyagi; Indu Kohaar; Suresh Hedau; Alok C. Bharti; Subhodeep Sarker; Dipankar Dey; Daman Saluja; Bhudev Das

doi:10.3332/ecancer.2015.525

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

Alok Mishra^*, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C. Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Original language	English
Article number	525
Journal	ecancermedicalscience
Volume	9
DOIs	https://doi.org/10.3332/ecancer.2015.525
State	Published - 22 Apr 2015
Externally published	Yes

Keywords

Activator protein-1 (ap-1)
Curcumin
Human papilloma virus (hpa)
Nuclear factor kappab (nf-kb)
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10.3332/ecancer.2015.525

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abstract = "In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.",

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AU - Mishra, Alok

AU - Kumar, Rakesh

AU - Tyagi, Abhishek

AU - Kohaar, Indu

AU - Hedau, Suresh

AU - Bharti, Alok C.

AU - Sarker, Subhodeep

AU - Dey, Dipankar

AU - Saluja, Daman

AU - Das, Bhudev

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PY - 2015/4/22

Y1 - 2015/4/22

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AB - In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

KW - Activator protein-1 (ap-1)

KW - Curcumin

KW - Human papilloma virus (hpa)

KW - Nuclear factor kappab (nf-kb)

KW - Transcription

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JO - ecancermedicalscience

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Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

Abstract

Keywords

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