Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

Alok Mishra; Rakesh Kumar; Abhishek Tyagi; Indu Kohaar; Suresh Hedau; Alok C. Bharti; Subhodeep Sarker; Dipankar Dey; Daman Saluja; Bhudev Das

doi:10.3332/ecancer.2015.525

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

Alok Mishra^*
, Rakesh Kumar
, Abhishek Tyagi
, Indu Kohaar
, Suresh Hedau
, Alok C. Bharti
, Subhodeep Sarker
, Dipankar Dey
, Daman Saluja
, Bhudev Das

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Original language	English
Article number	525
Journal	ecancermedicalscience
Volume	9
DOIs	https://doi.org/10.3332/ecancer.2015.525
State	Published - 22 Apr 2015

Keywords

Activator protein-1 (ap-1)
Curcumin
Human papilloma virus (hpa)
Nuclear factor kappab (nf-kb)
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10.3332/ecancer.2015.525

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abstract = "In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.",

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AU - Mishra, Alok

AU - Kumar, Rakesh

AU - Tyagi, Abhishek

AU - Kohaar, Indu

AU - Hedau, Suresh

AU - Bharti, Alok C.

AU - Sarker, Subhodeep

AU - Dey, Dipankar

AU - Saluja, Daman

AU - Das, Bhudev

PY - 2015/4/22

Y1 - 2015/4/22

N2 - In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

AB - In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

KW - Activator protein-1 (ap-1)

KW - Curcumin

KW - Human papilloma virus (hpa)

KW - Nuclear factor kappab (nf-kb)

KW - Transcription

UR - https://www.scopus.com/pages/publications/84934963035

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DO - 10.3332/ecancer.2015.525

M3 - Article

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SN - 1754-6605

VL - 9

JO - ecancermedicalscience

JF - ecancermedicalscience

M1 - 525

ER -

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

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Keywords

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