Current and emerging therapies in nonalcoholic fatty liver disease

Maryam R. Kashi, Dawn M. Torres, Stephen A. Harrison

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


The prevalence of obesity and the metabolic syndrome (MS) is on the rise, and subsequently the hepaticmanifestation of MS, nonalcoholic fatty liver disease (NAFLD), has become a common entity in clinical practice. Most patients with NAFLD face medical complications related to their underlying MS in other organ systems; however, a small but significant group of patients with the more aggressive form of fatty liver, nonalcoholic steatohepatitis (NASH), are at risk of developing cirrhosis and hepatocellular carcinoma. As patients are generally asymptomatic, often their disease goes unrecognized. This is particularly true for NASH, where liver biopsy is currently required to make the diagnosis. Once diagnosed, no one treatment has been shown to be universally efficacious and those that are of benefit are not without side effects. Effective treatment regimens directed at both decreasing insulin resistance as well as the processes leading to necroinflammation and hepatic fibrosis have been investigated and include lifestyle modification, surgical therapies, and pharmacotherapy. This review focuses on current and potential future therapies for NASH.

Original languageEnglish
Pages (from-to)396-406
Number of pages11
JournalSeminars in Liver Disease
Issue number4
StatePublished - Nov 2008
Externally publishedYes


  • Fatty liver
  • Metabolic syndrome
  • Nonalcoholic fatty liver disease (NAFLD)
  • Nonalcoholic steatohepatitis (NASH)
  • Thiazolidinediones (TZDs)


Dive into the research topics of 'Current and emerging therapies in nonalcoholic fatty liver disease'. Together they form a unique fingerprint.

Cite this