Current status of intravenous immunoglobuiin in preventing or treating neonatal bacterial infections

Leonard E. Weisman*, David F. Cruess, Gerald W. Fischer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Although current studies suggest that IVIG is safe, larger controlled trials will soon be published and will be important to confirm this observation. In addition, the current studies do not establish the efficacy of IVIG for either treating or preventing neonatal bacterial infections. Some studies with small numbers of babies suggest benefit of IVIG therapy and prophylaxis; however, the studies reviewed do not, individually or combined, prove efficacy. Clinicians and investigators must not confuse studies that prevent infection with those that treat infection, since different therapeutic regimens may be necessary. Many questions remain concerning IVIG therapy, such as: Is IVIG efficacious in preventing or treating neonatal sepsis? What is the appropriate immunoglobulin dosage? How variable is the pathogen-specific antibody activity of standard IVIG products? For effectively determining the appropriate use of IVIG in neonates, well-designed and carefully controlled trials are needed to address these issues, using sufficiently large numbers of babies to arrive at valid scientific conclusions. Although many questions will be answered with the trials currently in progress, we must continue to base further recommendations for immunoglobulin therapy on solid scientific data.

Original languageEnglish
Pages (from-to)13-28
Number of pages16
JournalClinical Reviews in Allergy
Issue number1-2
StatePublished - Mar 1992
Externally publishedYes


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