Cyclosporine-induced hyperuricemia and gout

William Douglas Figg; T. C. Noordzij; K. M.L. Leunissen; J. P. Van Hooff; Richard P. Wedeen; Irving H. Fox

doi:10.1056/NEJM199002013220514

Cyclosporine-induced hyperuricemia and gout

William Douglas Figg, T. C. Noordzij, K. M.L. Leunissen, J. P. Van Hooff, Richard P. Wedeen, Irving H. Fox

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

To the Editor: Could Lin et al. (Aug. 3 issue)¹ give their recommendations on how to treat transplant recipients with gouty arthritis? The care of these patients is complicated by the existence of a potentially serious drug interaction between allopurinol and azathioprine. Allopurinol is a xanthine oxidase inhibitor and an important part of the armamentarium for the treatment of gout. Azathioprine is an immunosuppressive agent used primarily with cyclosporine and prednisone for the prevention of organ rejection in transplant recipients. The pathway responsible for the metabolism of azathioprine is xanthine oxidase. The inhibition of this pathway may therefore result in.

Original language	English
Pages (from-to)	334-336
Number of pages	3
Journal	New England Journal of Medicine
Volume	322
Issue number	5
DOIs	https://doi.org/10.1056/NEJM199002013220514
State	Published - 1 Feb 1990
Externally published	Yes

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title = "Cyclosporine-induced hyperuricemia and gout",

abstract = "To the Editor: Could Lin et al. (Aug. 3 issue)1 give their recommendations on how to treat transplant recipients with gouty arthritis? The care of these patients is complicated by the existence of a potentially serious drug interaction between allopurinol and azathioprine. Allopurinol is a xanthine oxidase inhibitor and an important part of the armamentarium for the treatment of gout. Azathioprine is an immunosuppressive agent used primarily with cyclosporine and prednisone for the prevention of organ rejection in transplant recipients. The pathway responsible for the metabolism of azathioprine is xanthine oxidase. The inhibition of this pathway may therefore result in.",

author = "Figg, {William Douglas} and Noordzij, {T. C.} and Leunissen, {K. M.L.} and {Van Hooff}, {J. P.} and Wedeen, {Richard P.} and Fox, {Irving H.}",

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T1 - Cyclosporine-induced hyperuricemia and gout

AU - Figg, William Douglas

AU - Noordzij, T. C.

AU - Leunissen, K. M.L.

AU - Van Hooff, J. P.

AU - Wedeen, Richard P.

AU - Fox, Irving H.

PY - 1990/2/1

Y1 - 1990/2/1

N2 - To the Editor: Could Lin et al. (Aug. 3 issue)1 give their recommendations on how to treat transplant recipients with gouty arthritis? The care of these patients is complicated by the existence of a potentially serious drug interaction between allopurinol and azathioprine. Allopurinol is a xanthine oxidase inhibitor and an important part of the armamentarium for the treatment of gout. Azathioprine is an immunosuppressive agent used primarily with cyclosporine and prednisone for the prevention of organ rejection in transplant recipients. The pathway responsible for the metabolism of azathioprine is xanthine oxidase. The inhibition of this pathway may therefore result in.

AB - To the Editor: Could Lin et al. (Aug. 3 issue)1 give their recommendations on how to treat transplant recipients with gouty arthritis? The care of these patients is complicated by the existence of a potentially serious drug interaction between allopurinol and azathioprine. Allopurinol is a xanthine oxidase inhibitor and an important part of the armamentarium for the treatment of gout. Azathioprine is an immunosuppressive agent used primarily with cyclosporine and prednisone for the prevention of organ rejection in transplant recipients. The pathway responsible for the metabolism of azathioprine is xanthine oxidase. The inhibition of this pathway may therefore result in.

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VL - 322

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

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Cyclosporine-induced hyperuricemia and gout

Abstract

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