DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing

W. G. Land; P. Agostinis; S. Gasser; A. D. Garg; A. Linkermann; Dietmar K. Abendroth; Dieter Adam; Hans Joachim Anders; Helmut P. Arbogast; Carla Baan; Seiamak Bahram; Jan Ulrich Becker; Joseph V. Bonventre; Jan Hinrich Bräsen; Lloyd G. Cantley; Anil Chandraker; Abdallah Daar; Ilse Daehn; Dushka Dragun; Jean Michel Dubernard; Christine S. Falk; Philippe Georgel; Douglas R. Green; Josep Grinyo; Mehmet Haberal; Hermann Haller; Philip F. Halloran; Jan Ole Heller; Alexandre Hertig; Luuk Hilbrands; Tobias B. Huber; Ottmar Janssen; Anthony M. Jevnikar; Allan D. Kirk; Richard N. Kitsis; Jerzy Kupiec-Weglinski; Ulrich Kunzendorf; Guido Kroemer; Christian Kurts; Daqing Ma; Jonathan Maltzman; Raimund Margreiter; Gilbert Massard; Konrad Messmer; Randall Morris; James Murphy; Björn Nashan; Andrew Oberst; Alberto Ortiz; Mike Overholtzer; Claudio Ponticelli; David M. Rothstein; Ana B. Sanz; Mario Schiffer; Bernd Schröppel; Kevin Schulte; S. Y. Seong; Jean Sibilia; Andrew M. Siedlecki; Hans Werner Sollinger; Terry B. Strom; Brent R. Stockwell; Attila J. Szabó; Wulf Tonnus; H. L. Trivedi; Stephan G. Tullius; Laurence A. Turka; Heth Turnquist; Peter Vandenabeele; Tom Vanden Berghe; Henning Walczak; Joel M. Weinberg; Philippe Wolf; Adrian Zierleyn

doi:10.1111/ajt.14012

DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing

W. G. Land^*, P. Agostinis, S. Gasser, A. D. Garg, A. Linkermann, Dietmar K. Abendroth, Dieter Adam, Hans Joachim Anders, Helmut P. Arbogast, Carla Baan, Seiamak Bahram, Jan Ulrich Becker, Joseph V. Bonventre, Jan Hinrich Bräsen, Lloyd G. Cantley, Anil Chandraker, Abdallah Daar, Ilse Daehn, Dushka Dragun, Jean Michel DubernardChristine S. Falk, Philippe Georgel, Douglas R. Green, Josep Grinyo, Mehmet Haberal, Hermann Haller, Philip F. Halloran, Jan Ole Heller, Alexandre Hertig, Luuk Hilbrands, Tobias B. Huber, Ottmar Janssen, Anthony M. Jevnikar, Allan D. Kirk, Richard N. Kitsis, Jerzy Kupiec-Weglinski, Ulrich Kunzendorf, Guido Kroemer, Christian Kurts, Daqing Ma, Jonathan Maltzman, Raimund Margreiter, Gilbert Massard, Konrad Messmer, Randall Morris, James Murphy, Björn Nashan, Andrew Oberst, Alberto Ortiz, Mike Overholtzer, Claudio Ponticelli, David M. Rothstein, Ana B. Sanz, Mario Schiffer, Bernd Schröppel, Kevin Schulte, S. Y. Seong, Jean Sibilia, Andrew M. Siedlecki, Hans Werner Sollinger, Terry B. Strom, Brent R. Stockwell, Attila J. Szabó, Wulf Tonnus, H. L. Trivedi, Stephan G. Tullius, Laurence A. Turka, Heth Turnquist, Peter Vandenabeele, Tom Vanden Berghe, Henning Walczak, Joel M. Weinberg, Philippe Wolf, Adrian Zierleyn

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Review article › peer-review

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Abstract

The pathophysiological importance of the immunogenicity of damage-associated molecular patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection following release from dying cells, such as after ischemia–reperfusion injury. In cancers, however, this strong trigger of a specific immune response gives rise to the success of cancer immunotherapy. Here, we review the recently literature on the pathophysiological importance of DAMP release and discuss the implications of these processes for allograft rejection and cancer immunotherapy, revealing a striking mechanistic overlap. We conclude that these two fields share a common mechanistic basis of regulated necrosis and inflammation, the molecular characterization of which may be helpful for both oncologists and the transplant community.

Original language	English
Pages (from-to)	3322-3337
Number of pages	16
Journal	American Journal of Transplantation
Volume	16
Issue number	12
DOIs	https://doi.org/10.1111/ajt.14012
State	Published - 1 Dec 2016

Keywords

basic (laboratory) research/science
cancer/malignancy/neoplasia
cell death
immune regulation
immunobiology
organ transplantation in general
rejection
rejection: antibody-mediated (ABMR)
translational research/science

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10.1111/ajt.14012

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Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., Linkermann, A., Abendroth, D. K., Adam, D., Anders, H. J., Arbogast, H. P., Baan, C., Bahram, S., Becker, J. U., Bonventre, J. V., Bräsen, J. H., Cantley, L. G., Chandraker, A., Daar, A., Daehn, I., Dragun, D., ... Zierleyn, A. (2016). DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing. American Journal of Transplantation, 16(12), 3322-3337. https://doi.org/10.1111/ajt.14012

@article{79bd765936fe4c48bc300418a78d6781,

title = "DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing",

abstract = "The pathophysiological importance of the immunogenicity of damage-associated molecular patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection following release from dying cells, such as after ischemia–reperfusion injury. In cancers, however, this strong trigger of a specific immune response gives rise to the success of cancer immunotherapy. Here, we review the recently literature on the pathophysiological importance of DAMP release and discuss the implications of these processes for allograft rejection and cancer immunotherapy, revealing a striking mechanistic overlap. We conclude that these two fields share a common mechanistic basis of regulated necrosis and inflammation, the molecular characterization of which may be helpful for both oncologists and the transplant community.",

keywords = "basic (laboratory) research/science, cancer/malignancy/neoplasia, cell death, immune regulation, immunobiology, organ transplantation in general, rejection, rejection: antibody-mediated (ABMR), translational research/science",

author = "Land, {W. G.} and P. Agostinis and S. Gasser and Garg, {A. D.} and A. Linkermann and Abendroth, {Dietmar K.} and Dieter Adam and Anders, {Hans Joachim} and Arbogast, {Helmut P.} and Carla Baan and Seiamak Bahram and Becker, {Jan Ulrich} and Bonventre, {Joseph V.} and Br{\"a}sen, {Jan Hinrich} and Cantley, {Lloyd G.} and Anil Chandraker and Abdallah Daar and Ilse Daehn and Dushka Dragun and Dubernard, {Jean Michel} and Falk, {Christine S.} and Philippe Georgel and Green, {Douglas R.} and Josep Grinyo and Mehmet Haberal and Hermann Haller and Halloran, {Philip F.} and Heller, {Jan Ole} and Alexandre Hertig and Luuk Hilbrands and Huber, {Tobias B.} and Ottmar Janssen and Jevnikar, {Anthony M.} and Kirk, {Allan D.} and Kitsis, {Richard N.} and Jerzy Kupiec-Weglinski and Ulrich Kunzendorf and Guido Kroemer and Christian Kurts and Daqing Ma and Jonathan Maltzman and Raimund Margreiter and Gilbert Massard and Konrad Messmer and Randall Morris and James Murphy and Bj{\"o}rn Nashan and Andrew Oberst and Alberto Ortiz and Mike Overholtzer and Claudio Ponticelli and Rothstein, {David M.} and Sanz, {Ana B.} and Mario Schiffer and Bernd Schr{\"o}ppel and Kevin Schulte and Seong, {S. Y.} and Jean Sibilia and Siedlecki, {Andrew M.} and Sollinger, {Hans Werner} and Strom, {Terry B.} and Stockwell, {Brent R.} and Szab{\'o}, {Attila J.} and Wulf Tonnus and Trivedi, {H. L.} and Tullius, {Stephan G.} and Turka, {Laurence A.} and Heth Turnquist and Peter Vandenabeele and {Vanden Berghe}, Tom and Henning Walczak and Weinberg, {Joel M.} and Philippe Wolf and Adrian Zierleyn",

year = "2016",

month = dec,

day = "1",

doi = "10.1111/ajt.14012",

language = "English",

volume = "16",

pages = "3322--3337",

journal = "American Journal of Transplantation",

issn = "1600-6135",

number = "12",

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Land, WG, Agostinis, P, Gasser, S, Garg, AD, Linkermann, A, Abendroth, DK, Adam, D, Anders, HJ, Arbogast, HP, Baan, C, Bahram, S, Becker, JU, Bonventre, JV, Bräsen, JH, Cantley, LG, Chandraker, A, Daar, A, Daehn, I, Dragun, D, Dubernard, JM, Falk, CS, Georgel, P, Green, DR, Grinyo, J, Haberal, M, Haller, H, Halloran, PF, Heller, JO, Hertig, A, Hilbrands, L, Huber, TB, Janssen, O, Jevnikar, AM, Kirk, AD, Kitsis, RN, Kupiec-Weglinski, J, Kunzendorf, U, Kroemer, G, Kurts, C, Ma, D, Maltzman, J, Margreiter, R, Massard, G, Messmer, K, Morris, R, Murphy, J, Nashan, B, Oberst, A, Ortiz, A, Overholtzer, M, Ponticelli, C, Rothstein, DM, Sanz, AB, Schiffer, M, Schröppel, B, Schulte, K, Seong, SY, Sibilia, J, Siedlecki, AM, Sollinger, HW, Strom, TB, Stockwell, BR, Szabó, AJ, Tonnus, W, Trivedi, HL, Tullius, SG, Turka, LA, Turnquist, H, Vandenabeele, P, Vanden Berghe, T, Walczak, H, Weinberg, JM, Wolf, P & Zierleyn, A 2016, 'DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing', American Journal of Transplantation, vol. 16, no. 12, pp. 3322-3337. https://doi.org/10.1111/ajt.14012

TY - JOUR

T1 - DAMP—Induced Allograft and Tumor Rejection

T2 - The Circle Is Closing

AU - Land, W. G.

AU - Agostinis, P.

AU - Gasser, S.

AU - Garg, A. D.

AU - Linkermann, A.

AU - Abendroth, Dietmar K.

AU - Adam, Dieter

AU - Anders, Hans Joachim

AU - Arbogast, Helmut P.

AU - Baan, Carla

AU - Bahram, Seiamak

AU - Becker, Jan Ulrich

AU - Bonventre, Joseph V.

AU - Bräsen, Jan Hinrich

AU - Cantley, Lloyd G.

AU - Chandraker, Anil

AU - Daar, Abdallah

AU - Daehn, Ilse

AU - Dragun, Dushka

AU - Dubernard, Jean Michel

AU - Falk, Christine S.

AU - Georgel, Philippe

AU - Green, Douglas R.

AU - Grinyo, Josep

AU - Haberal, Mehmet

AU - Haller, Hermann

AU - Halloran, Philip F.

AU - Heller, Jan Ole

AU - Hertig, Alexandre

AU - Hilbrands, Luuk

AU - Huber, Tobias B.

AU - Janssen, Ottmar

AU - Jevnikar, Anthony M.

AU - Kirk, Allan D.

AU - Kitsis, Richard N.

AU - Kupiec-Weglinski, Jerzy

AU - Kunzendorf, Ulrich

AU - Kroemer, Guido

AU - Kurts, Christian

AU - Ma, Daqing

AU - Maltzman, Jonathan

AU - Margreiter, Raimund

AU - Massard, Gilbert

AU - Messmer, Konrad

AU - Morris, Randall

AU - Murphy, James

AU - Nashan, Björn

AU - Oberst, Andrew

AU - Ortiz, Alberto

AU - Overholtzer, Mike

AU - Ponticelli, Claudio

AU - Rothstein, David M.

AU - Sanz, Ana B.

AU - Schiffer, Mario

AU - Schröppel, Bernd

AU - Schulte, Kevin

AU - Seong, S. Y.

AU - Sibilia, Jean

AU - Siedlecki, Andrew M.

AU - Sollinger, Hans Werner

AU - Strom, Terry B.

AU - Stockwell, Brent R.

AU - Szabó, Attila J.

AU - Tonnus, Wulf

AU - Trivedi, H. L.

AU - Tullius, Stephan G.

AU - Turka, Laurence A.

AU - Turnquist, Heth

AU - Vandenabeele, Peter

AU - Vanden Berghe, Tom

AU - Walczak, Henning

AU - Weinberg, Joel M.

AU - Wolf, Philippe

AU - Zierleyn, Adrian

PY - 2016/12/1

Y1 - 2016/12/1

N2 - The pathophysiological importance of the immunogenicity of damage-associated molecular patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection following release from dying cells, such as after ischemia–reperfusion injury. In cancers, however, this strong trigger of a specific immune response gives rise to the success of cancer immunotherapy. Here, we review the recently literature on the pathophysiological importance of DAMP release and discuss the implications of these processes for allograft rejection and cancer immunotherapy, revealing a striking mechanistic overlap. We conclude that these two fields share a common mechanistic basis of regulated necrosis and inflammation, the molecular characterization of which may be helpful for both oncologists and the transplant community.

AB - The pathophysiological importance of the immunogenicity of damage-associated molecular patterns (DAMPs) has been pinpointed by their identification as triggers of allograft rejection following release from dying cells, such as after ischemia–reperfusion injury. In cancers, however, this strong trigger of a specific immune response gives rise to the success of cancer immunotherapy. Here, we review the recently literature on the pathophysiological importance of DAMP release and discuss the implications of these processes for allograft rejection and cancer immunotherapy, revealing a striking mechanistic overlap. We conclude that these two fields share a common mechanistic basis of regulated necrosis and inflammation, the molecular characterization of which may be helpful for both oncologists and the transplant community.

KW - basic (laboratory) research/science

KW - cancer/malignancy/neoplasia

KW - cell death

KW - immune regulation

KW - immunobiology

KW - organ transplantation in general

KW - rejection

KW - rejection: antibody-mediated (ABMR)

KW - translational research/science

UR - http://www.scopus.com/inward/record.url?scp=84988336228&partnerID=8YFLogxK

U2 - 10.1111/ajt.14012

DO - 10.1111/ajt.14012

M3 - Review article

C2 - 27529775

AN - SCOPUS:84988336228

SN - 1600-6135

VL - 16

SP - 3322

EP - 3337

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 12

ER -

DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing

Abstract

Keywords

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