Decellularized biological scaffolds for cardiac repair and regeneration

D. M. Faulk, S. A. Johnson, S. F. Badylak*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

8 Scopus citations


Biological scaffold materials composed of extracellular matrix (ECM) provide a viable option for the repair and reconstruction of injured or missing cardiac tissue. Such biological scaffold materials are typically manufactured by decellularization of allogeneic or xenogeneic tissues with retention of the native ECM ultrastructure and composition. The method of ECM scaffold preparation has been shown to profoundly affect downstream remodeling events and clinical efficacy. Clinical applications, methods of manufacturing, results of preclinical studies, and speculation regarding the future use of such scaffold materials in cardiac reconstruction will be discussed.

Original languageEnglish
Title of host publicationCardiac Regeneration and Repair
Subtitle of host publicationBiomaterials and Tissue Engineering
PublisherElsevier Ltd
Number of pages21
ISBN (Print)9780857096593
StatePublished - Feb 2014
Externally publishedYes


  • Acellular bioscaffold
  • Biological scaffolds
  • Cardiac tissue engineering
  • Decellularized tissue
  • Extracellular matrix
  • Whole organ engineering


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