Deciphering the complexity of acute inflammation using mathematical models

Yoram Vodovotz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Various stresses elicit an acute, complex inflammatory response, leading to healing but sometimes also to organ dysfunction and death. We constructed both equation-based models (EBM) and agent-based models (ABM) of various degrees of granularity- which encompass the dynamics of relevant cells, cytokines, and the resulting global tissue dysfunction-in order to begin to unravel these inflammatory interactions. The EBMs describe and predict various features of septic shock and trauma/hemorrhage (including the response to anthrax, preconditioning phenomena, and irreversible hemorrhage) and were used to simulate anti-inflammatory strategies in clinical trials. The ABMs that describe the interrelationship between inflammation and wound healing yielded insights into intestinal healing in necrotizing enterocolitis, vocal fold healing during phonotrauma, and skin healing in the setting of diabetic foot ulcers. Modeling may help in understanding the complex interactions among the components of inflammation and response to stress, and therefore aid in the development of novel therapies and diagnostics.

Original languageEnglish
Pages (from-to)237-245
Number of pages9
JournalImmunologic Research
Volume36
Issue number1-3
DOIs
StatePublished - Sep 2006

Keywords

  • Inflammation
  • Mathematical model
  • Sepsis
  • Trauma
  • Wound healing

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