Deployment-associated exposure surveillance with high-resolution metabolomics

Douglas I. Walker, Timothy M. Mallon, Philip K. Hopke, Karan Uppal, Young Mi Go, Patricia Rohrbeck, Kurt D. Pennell, Dean P. Jones*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Objective: The aim of this study was to assess the suitability of high-resolution metabolomics (HRM) for measure of internal exposure and effect biomarkers from deployment-related environmental hazards. Methods: HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent applications of HRM as a prototype environmental exposure surveillance system. Results: Building upon techniques available for contemporary occupational medicine and exposure sciences, HRM methods are able to integrate external exposures, internal body burden of environmental agents, and relevant biological responses with health outcomes. Conclusions: Systematic analysis of existing Department of Defense Serum Repository samples will provide a high-quality, cross-sectional reference dataset for deployment-associated exposures while at the same time establishing a foundation for precision medicine.

Original languageEnglish
Pages (from-to)S12-S21
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number8S
DOIs
StatePublished - 1 Aug 2016
Externally publishedYes

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