Desensitization of 5-HT1A autoreceptors by chronic administration of 8-OH-DPAT

Deborah S. Kreiss; Irwin Lucki

doi:10.1016/0028-3908(92)90110-B

Desensitization of 5-HT_1A autoreceptors by chronic administration of 8-OH-DPAT

Deborah S. Kreiss^*
, Irwin Lucki

^*Corresponding author for this work

Pharmacology and Molecular Therapeutics

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The function of 5-HT_1A autoreceptors was examined by measuring the ability of the 5-HT_1A receptor agonist 8-OH-DPAT to reduce 5-HT release in the striatum using in vivo microdialysis. 8-OH-DPAT reduced the release of 5-HT in the striatum. Chronic treatment with 8-OH-DPAT (1.0 mg/kg s.c.) for 7 days, but not 1 day, attenuated the effect of an acute challenge dose of 8-OH-DPAT. The results of the present study indicate that in vivo microdialysis can be used to study the effects of activation of 5-HT_1A autoreceptors on 5-HT release and the regulation of 5-HT release by chronic administration of psychoactive drugs.

Original language	English
Pages (from-to)	1073-1076
Number of pages	4
Journal	Neuropharmacology
Volume	31
Issue number	10
DOIs	https://doi.org/10.1016/0028-3908(92)90110-B
State	Published - Oct 1992

Keywords

5-HT release
5-HT receptors
8-OH-DPAT
antidepressants
densensitization
microdialysis

Access to Document

10.1016/0028-3908(92)90110-B

Cite this

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title = "Desensitization of 5-HT1A autoreceptors by chronic administration of 8-OH-DPAT",

abstract = "The function of 5-HT1A autoreceptors was examined by measuring the ability of the 5-HT1A receptor agonist 8-OH-DPAT to reduce 5-HT release in the striatum using in vivo microdialysis. 8-OH-DPAT reduced the release of 5-HT in the striatum. Chronic treatment with 8-OH-DPAT (1.0 mg/kg s.c.) for 7 days, but not 1 day, attenuated the effect of an acute challenge dose of 8-OH-DPAT. The results of the present study indicate that in vivo microdialysis can be used to study the effects of activation of 5-HT1A autoreceptors on 5-HT release and the regulation of 5-HT release by chronic administration of psychoactive drugs.",

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T1 - Desensitization of 5-HT1A autoreceptors by chronic administration of 8-OH-DPAT

AU - Kreiss, Deborah S.

AU - Lucki, Irwin

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N2 - The function of 5-HT1A autoreceptors was examined by measuring the ability of the 5-HT1A receptor agonist 8-OH-DPAT to reduce 5-HT release in the striatum using in vivo microdialysis. 8-OH-DPAT reduced the release of 5-HT in the striatum. Chronic treatment with 8-OH-DPAT (1.0 mg/kg s.c.) for 7 days, but not 1 day, attenuated the effect of an acute challenge dose of 8-OH-DPAT. The results of the present study indicate that in vivo microdialysis can be used to study the effects of activation of 5-HT1A autoreceptors on 5-HT release and the regulation of 5-HT release by chronic administration of psychoactive drugs.

AB - The function of 5-HT1A autoreceptors was examined by measuring the ability of the 5-HT1A receptor agonist 8-OH-DPAT to reduce 5-HT release in the striatum using in vivo microdialysis. 8-OH-DPAT reduced the release of 5-HT in the striatum. Chronic treatment with 8-OH-DPAT (1.0 mg/kg s.c.) for 7 days, but not 1 day, attenuated the effect of an acute challenge dose of 8-OH-DPAT. The results of the present study indicate that in vivo microdialysis can be used to study the effects of activation of 5-HT1A autoreceptors on 5-HT release and the regulation of 5-HT release by chronic administration of psychoactive drugs.

KW - 5-HT release

KW - 5-HT receptors

KW - 8-OH-DPAT

KW - antidepressants

KW - densensitization

KW - microdialysis

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DO - 10.1016/0028-3908(92)90110-B

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