Design of possibly universal vaccines against seasonal influenza

Cecilia P. Mikita; Eduardo A. Padlan

Design of possibly universal vaccines against seasonal influenza

Cecilia P. Mikita
, Eduardo A. Padlan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The design of possibly universal vaccines against seasonal influenza is proposed. The vaccines are based on the hemagglutinin glycoprotein and are designed to focus the immune response to the cleavage site of the molecule. The chemical reactivity of the variable regions is reduced (de-Antigenized) by judicious amino acid replacements. Structurally important regions are preserved. The proposed vaccines make no distinction between trivalent and quadrivalent seasonal vaccines.

Original language	English
Pages (from-to)	12-28
Number of pages	17
Journal	SciEnggJ
Volume	14
Issue number	1
State	Published - 1 Jan 2021

Keywords

cleavage site epitope
hemagglutinin
universal vaccine
yearly influenza vaccine

Cite this

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title = "Design of possibly universal vaccines against seasonal influenza",

abstract = "The design of possibly universal vaccines against seasonal influenza is proposed. The vaccines are based on the hemagglutinin glycoprotein and are designed to focus the immune response to the cleavage site of the molecule. The chemical reactivity of the variable regions is reduced (de-Antigenized) by judicious amino acid replacements. Structurally important regions are preserved. The proposed vaccines make no distinction between trivalent and quadrivalent seasonal vaccines.",

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AB - The design of possibly universal vaccines against seasonal influenza is proposed. The vaccines are based on the hemagglutinin glycoprotein and are designed to focus the immune response to the cleavage site of the molecule. The chemical reactivity of the variable regions is reduced (de-Antigenized) by judicious amino acid replacements. Structurally important regions are preserved. The proposed vaccines make no distinction between trivalent and quadrivalent seasonal vaccines.

KW - cleavage site epitope

KW - hemagglutinin

KW - universal vaccine

KW - yearly influenza vaccine

UR - https://www.scopus.com/pages/publications/85131731056

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VL - 14

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JO - SciEnggJ

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Design of possibly universal vaccines against seasonal influenza

Abstract

Keywords

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