Abstract
The design of possibly universal vaccines against seasonal influenza is proposed. The vaccines are based on the hemagglutinin glycoprotein and are designed to focus the immune response to the cleavage site of the molecule. The chemical reactivity of the variable regions is reduced (de-Antigenized) by judicious amino acid replacements. Structurally important regions are preserved. The proposed vaccines make no distinction between trivalent and quadrivalent seasonal vaccines.
| Original language | English |
|---|---|
| Pages (from-to) | 12-28 |
| Number of pages | 17 |
| Journal | SciEnggJ |
| Volume | 14 |
| Issue number | 1 |
| State | Published - 1 Jan 2021 |
Keywords
- cleavage site epitope
- hemagglutinin
- universal vaccine
- yearly influenza vaccine