Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine.

Melissa J Martin, Ting L Luo, Valentyn Kovalchuk, Viacheslav Kondratiuk, Henry D Dao, Iryna Kovalenko, Brandon J Plaza, Joanna M Kettlewell, Cole P Anderson, Jason R Smedberg, Ana C Ong, Yoon I Kwak, Joshua S Hawley-Molloy, Jason W Bennett, Patrick T McGann, Francois Lebreton

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Abstract

Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5, bla KPC-3, bla CTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.

Original languageEnglish
Pages (from-to)e0109024
JournalAntimicrobial Agents and Chemotherapy
DOIs
StateE-pub ahead of print - 20 Sep 2024

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