Detection of cefiderocol and aztreonam/avibactam resistance in epidemic 
        Escherichia coli ST-361 carrying 
        bla
        NDM-5 and 
        bla
        KPC-3 from foreign fighters evacuated from Ukraine.

Melissa J Martin; Ting L Luo; Valentyn Kovalchuk; Viacheslav Kondratiuk; Henry D Dao; Iryna Kovalenko; Brandon J Plaza; Joanna M Kettlewell; Cole P Anderson; Jason R Smedberg; Ana C Ong; Yoon I Kwak; Joshua S Hawley-Molloy; Jason W Bennett; Patrick T McGann; Francois Lebreton

doi:10.1128/aac.01090-24

Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine.

Melissa J Martin
, Ting L Luo
, Valentyn Kovalchuk
, Viacheslav Kondratiuk
, Henry D Dao
, Iryna Kovalenko
, Brandon J Plaza
, Joanna M Kettlewell
, Cole P Anderson
, Jason R Smedberg
, Ana C Ong
, Yoon I Kwak
, Joshua S Hawley-Molloy
, Jason W Bennett
, Patrick T McGann
, Francois Lebreton

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5, bla KPC-3, bla CTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.

Original language	English
Pages (from-to)	e0109024
Journal	Antimicrobial Agents and Chemotherapy
DOIs	https://doi.org/10.1128/aac.01090-24
State	E-pub ahead of print - 20 Sep 2024

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Martin, M. J., Luo, T. L., Kovalchuk, V., Kondratiuk, V., Dao, H. D., Kovalenko, I., Plaza, B. J., Kettlewell, J. M., Anderson, C. P., Smedberg, J. R., Ong, A. C., Kwak, Y. I., Hawley-Molloy, J. S., Bennett, J. W., McGann, P. T., & Lebreton, F. (2024). Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine. Antimicrobial Agents and Chemotherapy, e0109024. Advance online publication. https://doi.org/10.1128/aac.01090-24

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title = "Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine.",

abstract = "Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5, bla KPC-3, bla CTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine. ",

author = "Martin, \{Melissa J\} and Luo, \{Ting L\} and Valentyn Kovalchuk and Viacheslav Kondratiuk and Dao, \{Henry D\} and Iryna Kovalenko and Plaza, \{Brandon J\} and Kettlewell, \{Joanna M\} and Anderson, \{Cole P\} and Smedberg, \{Jason R\} and Ong, \{Ana C\} and Kwak, \{Yoon I\} and Hawley-Molloy, \{Joshua S\} and Bennett, \{Jason W\} and McGann, \{Patrick T\} and Francois Lebreton",

year = "2024",

month = sep,

day = "20",

doi = "10.1128/aac.01090-24",

language = "English",

pages = "e0109024",

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Martin, MJ, Luo, TL, Kovalchuk, V, Kondratiuk, V, Dao, HD, Kovalenko, I, Plaza, BJ, Kettlewell, JM, Anderson, CP, Smedberg, JR, Ong, AC, Kwak, YI, Hawley-Molloy, JS, Bennett, JW, McGann, PT & Lebreton, F 2024, 'Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine.', Antimicrobial Agents and Chemotherapy, pp. e0109024. https://doi.org/10.1128/aac.01090-24

Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine. / Martin, Melissa J; Luo, Ting L; Kovalchuk, Valentyn et al.
In: Antimicrobial Agents and Chemotherapy, 20.09.2024, p. e0109024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine.

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AU - Kovalchuk, Valentyn

AU - Kondratiuk, Viacheslav

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AU - Anderson, Cole P

AU - Smedberg, Jason R

AU - Ong, Ana C

AU - Kwak, Yoon I

AU - Hawley-Molloy, Joshua S

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AU - McGann, Patrick T

AU - Lebreton, Francois

PY - 2024/9/20

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N2 - Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5, bla KPC-3, bla CTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.

AB - Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5, bla KPC-3, bla CTX-M-15, and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.

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ER -

Martin MJ, Luo TL, Kovalchuk V, Kondratiuk V, Dao HD, Kovalenko I et al. Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine. Antimicrobial Agents and Chemotherapy. 2024 Sep 20;e0109024. Epub 2024 Sep 20. doi: 10.1128/aac.01090-24

Detection of cefiderocol and aztreonam/avibactam resistance in epidemic Escherichia coli ST-361 carrying bla NDM-5 and bla KPC-3 from foreign fighters evacuated from Ukraine.

Abstract

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