Detection of diverse HIV-1 genetic subtypes in the USA

S. K. Brodine; F. C. Garland; J. R. Mascola; K. R. Porter; J. R. Mascola; A. W. Artenstein; D. S. Burke; P. J. Weiss; F. E. McCutchan

doi:10.1016/S0140-6736(95)92901-0

Detection of diverse HIV-1 genetic subtypes in the USA

S. K. Brodine^*, F. C. Garland, J. R. Mascola, K. R. Porter, J. R. Mascola, A. W. Artenstein, D. S. Burke, P. J. Weiss, F. E. McCutchan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

Of the nine genetic subtypes of HIV-1 that exist world wide, subtype B predominates in North America and Europe. Thus, most knowledge about HIV-1 and most vaccine development efforts are based on subtype B viruses. We document here the detection of HIV-1 subtypes A, D, and E in five US servicemen who acquired these non-subtype-B infections during overseas deployments. The dispersal of diverse HIV-1 subtypes into regions of the world with previously restricted genetic diversity may have important implications for the epidemiology of the epidemic and for the design and implementation of vaccine trials.

Original language	English
Pages (from-to)	1198-1199
Number of pages	2
Journal	The Lancet
Volume	346
Issue number	8984
DOIs	https://doi.org/10.1016/S0140-6736(95)92901-0
State	Published - 4 Nov 1995
Externally published	Yes

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title = "Detection of diverse HIV-1 genetic subtypes in the USA",

abstract = "Of the nine genetic subtypes of HIV-1 that exist world wide, subtype B predominates in North America and Europe. Thus, most knowledge about HIV-1 and most vaccine development efforts are based on subtype B viruses. We document here the detection of HIV-1 subtypes A, D, and E in five US servicemen who acquired these non-subtype-B infections during overseas deployments. The dispersal of diverse HIV-1 subtypes into regions of the world with previously restricted genetic diversity may have important implications for the epidemiology of the epidemic and for the design and implementation of vaccine trials.",

author = "Brodine, {S. K.} and Garland, {F. C.} and Mascola, {J. R.} and Porter, {K. R.} and Mascola, {J. R.} and Artenstein, {A. W.} and Burke, {D. S.} and Weiss, {P. J.} and McCutchan, {F. E.}",

year = "1995",

month = nov,

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doi = "10.1016/S0140-6736(95)92901-0",

language = "English",

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pages = "1198--1199",

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TY - JOUR

T1 - Detection of diverse HIV-1 genetic subtypes in the USA

AU - Brodine, S. K.

AU - Garland, F. C.

AU - Mascola, J. R.

AU - Porter, K. R.

AU - Mascola, J. R.

AU - Artenstein, A. W.

AU - Burke, D. S.

AU - Weiss, P. J.

AU - McCutchan, F. E.

PY - 1995/11/4

Y1 - 1995/11/4

N2 - Of the nine genetic subtypes of HIV-1 that exist world wide, subtype B predominates in North America and Europe. Thus, most knowledge about HIV-1 and most vaccine development efforts are based on subtype B viruses. We document here the detection of HIV-1 subtypes A, D, and E in five US servicemen who acquired these non-subtype-B infections during overseas deployments. The dispersal of diverse HIV-1 subtypes into regions of the world with previously restricted genetic diversity may have important implications for the epidemiology of the epidemic and for the design and implementation of vaccine trials.

AB - Of the nine genetic subtypes of HIV-1 that exist world wide, subtype B predominates in North America and Europe. Thus, most knowledge about HIV-1 and most vaccine development efforts are based on subtype B viruses. We document here the detection of HIV-1 subtypes A, D, and E in five US servicemen who acquired these non-subtype-B infections during overseas deployments. The dispersal of diverse HIV-1 subtypes into regions of the world with previously restricted genetic diversity may have important implications for the epidemiology of the epidemic and for the design and implementation of vaccine trials.

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U2 - 10.1016/S0140-6736(95)92901-0

DO - 10.1016/S0140-6736(95)92901-0

M3 - Article

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AN - SCOPUS:0028828669

SN - 0140-6736

VL - 346

SP - 1198

EP - 1199

JO - The Lancet

JF - The Lancet

IS - 8984

ER -

Detection of diverse HIV-1 genetic subtypes in the USA

Abstract

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