Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3

Kristi Y. Lee, Erica L. Beatson, Martina A. Knechel, Elijah R. Sommer, Giulia C. Napoli, Emily N. Risdon, Andres F. Leon, Roger D. Depaz, Jonathan D. Strope, Douglas K. Price, Cindy H. Chau, William D. Figg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Extracellular vesicles (EVs) provide a minimally invasive liquid biopsy source of tumor-specific markers for patients who have already undergone prostatectomies. Our laboratory has previously demonstrated enrichment of the cancer-type solute carrier organic anion transporter family 1B3 (ct-SLCO1B3) and the ATP Binding Cassette Subfamily Member C (ABCC3) in castration-resistant cell lines (CRPC). However, their expression in EVs has yet to be explored. Our study demonstrated that ct-SLCO1B3 and ABCC3 are highly detectable in CRPC cell line-derived EVs. We also showed that ct-SLCO1B3 and ABCC3 were detectable in a CRPC xenograft mouse model, both intratumorally and in plasma-derived EVs. Our results provide evidence for EV-contained ct-SLCO1B3 and ABCC3 as novel, EV-based tumor markers for prostate cancer progression.

Original languageEnglish
Pages (from-to)615-622
Number of pages8
JournalJournal of Cancer
Volume15
Issue number3
DOIs
StatePublished - 2024
Externally publishedYes

Keywords

  • ABCC3
  • Organic anion transporter family 1B3
  • SLCO1B3
  • cancer biomarker
  • extracellular vesicle
  • prostate cancer

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