Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection

Kurt H. Chau; George J. Dawson; Khalif M. Bile; Lars O. Magnius; Maria H. Sjogren; Isa K. Mushahwar

doi:10.1002/jmv.1890400414

Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection

Kurt H. Chau, George J. Dawson, Khalif M. Bile, Lars O. Magnius, Maria H. Sjogren, Isa K. Mushahwar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

A newly developed assay for IgA class antibody to hepatitis E virus (IgA anti‐HEV) was used to study 145 serum samples collected during an outbreak of an enterically transmitted hepatitis that occurred in 3 villages in the lower Shebeli region of Southern Somalia between January, 1988 and November, 1989. A total of 52.4% of the afflicted patients were found positive for IgA anti‐HEV, and 73.1% of these were also positive for IgM. Both antibodies disappeared during the convalescence period. Similar results were also seen in serum obtained from sporadic cases of acute waterborne hepatitis in Pakistan. © 1993 Wiley‐Liss, Inc.

Original language	English
Pages (from-to)	334-338
Number of pages	5
Journal	Journal of Medical Virology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1002/jmv.1890400414
State	Published - Aug 1993
Externally published	Yes

Keywords

HEV infection
anti‐HEV antibodies
hepatitis E virus HEV

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title = "Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection",

abstract = "A newly developed assay for IgA class antibody to hepatitis E virus (IgA anti‐HEV) was used to study 145 serum samples collected during an outbreak of an enterically transmitted hepatitis that occurred in 3 villages in the lower Shebeli region of Southern Somalia between January, 1988 and November, 1989. A total of 52.4% of the afflicted patients were found positive for IgA anti‐HEV, and 73.1% of these were also positive for IgM. Both antibodies disappeared during the convalescence period. Similar results were also seen in serum obtained from sporadic cases of acute waterborne hepatitis in Pakistan. {\textcopyright} 1993 Wiley‐Liss, Inc.",

keywords = "HEV infection, anti‐HEV antibodies, hepatitis E virus HEV",

author = "Chau, {Kurt H.} and Dawson, {George J.} and Bile, {Khalif M.} and Magnius, {Lars O.} and Sjogren, {Maria H.} and Mushahwar, {Isa K.}",

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T1 - Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection

AU - Chau, Kurt H.

AU - Dawson, George J.

AU - Bile, Khalif M.

AU - Magnius, Lars O.

AU - Sjogren, Maria H.

AU - Mushahwar, Isa K.

PY - 1993/8

Y1 - 1993/8

N2 - A newly developed assay for IgA class antibody to hepatitis E virus (IgA anti‐HEV) was used to study 145 serum samples collected during an outbreak of an enterically transmitted hepatitis that occurred in 3 villages in the lower Shebeli region of Southern Somalia between January, 1988 and November, 1989. A total of 52.4% of the afflicted patients were found positive for IgA anti‐HEV, and 73.1% of these were also positive for IgM. Both antibodies disappeared during the convalescence period. Similar results were also seen in serum obtained from sporadic cases of acute waterborne hepatitis in Pakistan. © 1993 Wiley‐Liss, Inc.

AB - A newly developed assay for IgA class antibody to hepatitis E virus (IgA anti‐HEV) was used to study 145 serum samples collected during an outbreak of an enterically transmitted hepatitis that occurred in 3 villages in the lower Shebeli region of Southern Somalia between January, 1988 and November, 1989. A total of 52.4% of the afflicted patients were found positive for IgA anti‐HEV, and 73.1% of these were also positive for IgM. Both antibodies disappeared during the convalescence period. Similar results were also seen in serum obtained from sporadic cases of acute waterborne hepatitis in Pakistan. © 1993 Wiley‐Liss, Inc.

KW - HEV infection

KW - anti‐HEV antibodies

KW - hepatitis E virus HEV

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EP - 338

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 4

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Detection of IgA class antibody to hepatitis E virus in serum samples from patients with hepatitis E virus infection

Abstract

Keywords

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