Detection of Neisseria gonorrhoeae from Joint Aspirate by Metagenomic Sequencing in Disseminated Gonococcal Infection

Betial Asmerom; Ian Drobish; Britanny Winckler; Leslie Chiang; Lauge Farnaes; Julia Beauchamp-Walters; John S. Bradley; Nanda Ramchandar

doi:10.1093/jpids/piaa108

Detection of Neisseria gonorrhoeae from Joint Aspirate by Metagenomic Sequencing in Disseminated Gonococcal Infection

Betial Asmerom
, Ian Drobish
, Britanny Winckler
, Leslie Chiang
, Lauge Farnaes
, Julia Beauchamp-Walters
, John S. Bradley
, Nanda Ramchandar^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI.

Original language	English
Pages (from-to)	367-369
Number of pages	3
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	10
Issue number	3
DOIs	https://doi.org/10.1093/jpids/piaa108
State	Published - 1 Mar 2021

Keywords

disseminated gonococcal infection
metagenomics
next-generation sequencing

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title = "Detection of Neisseria gonorrhoeae from Joint Aspirate by Metagenomic Sequencing in Disseminated Gonococcal Infection",

abstract = "Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI.",

keywords = "disseminated gonococcal infection, metagenomics, next-generation sequencing",

author = "Betial Asmerom and Ian Drobish and Britanny Winckler and Leslie Chiang and Lauge Farnaes and Julia Beauchamp-Walters and Bradley, \{John S.\} and Nanda Ramchandar",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected].",

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doi = "10.1093/jpids/piaa108",

language = "English",

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T1 - Detection of Neisseria gonorrhoeae from Joint Aspirate by Metagenomic Sequencing in Disseminated Gonococcal Infection

AU - Asmerom, Betial

AU - Drobish, Ian

AU - Winckler, Britanny

AU - Chiang, Leslie

AU - Farnaes, Lauge

AU - Beauchamp-Walters, Julia

AU - Bradley, John S.

AU - Ramchandar, Nanda

N1 - Publisher Copyright: © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: [email protected].

PY - 2021/3/1

Y1 - 2021/3/1

N2 - Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI.

AB - Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI.

KW - disseminated gonococcal infection

KW - metagenomics

KW - next-generation sequencing

UR - https://www.scopus.com/pages/publications/85104047017

U2 - 10.1093/jpids/piaa108

DO - 10.1093/jpids/piaa108

M3 - Article

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AN - SCOPUS:85104047017

SN - 2048-7193

VL - 10

SP - 367

EP - 369

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

IS - 3

ER -

Detection of Neisseria gonorrhoeae from Joint Aspirate by Metagenomic Sequencing in Disseminated Gonococcal Infection

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Keywords

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