Development of dengue DNA vaccines

Janine R. Danko*, Charmagne G. Beckett, Kevin R. Porter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine constructs and trials are underway to study these in the clinic. The scope of this review is to highlight the rich history of this vaccine platform and the work in dengue DNA vaccines accomplished by scientists at the Naval Medical Research Center. This work resulted in the only dengue DNA vaccine tested in a clinical trial to date. Additional advancements paving the road ahead in dengue DNA vaccine development are also discussed.

Original languageEnglish
Pages (from-to)7261-7266
Number of pages6
Issue number42
StatePublished - 23 Sep 2011
Externally publishedYes


  • Clinical trials
  • DNA vaccines
  • Dengue
  • Non-human primates
  • Shuffled DNA vaccines


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