Development of dengue DNA vaccines

Janine R. Danko; Charmagne G. Beckett; Kevin R. Porter

doi:10.1016/j.vaccine.2011.07.019

Development of dengue DNA vaccines

Janine R. Danko^*, Charmagne G. Beckett, Kevin R. Porter

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine constructs and trials are underway to study these in the clinic. The scope of this review is to highlight the rich history of this vaccine platform and the work in dengue DNA vaccines accomplished by scientists at the Naval Medical Research Center. This work resulted in the only dengue DNA vaccine tested in a clinical trial to date. Additional advancements paving the road ahead in dengue DNA vaccine development are also discussed.

Original language	English
Pages (from-to)	7261-7266
Number of pages	6
Journal	Vaccine
Volume	29
Issue number	42
DOIs	https://doi.org/10.1016/j.vaccine.2011.07.019
State	Published - 23 Sep 2011
Externally published	Yes

Keywords

Clinical trials
DNA vaccines
Dengue
Non-human primates
Shuffled DNA vaccines

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10.1016/j.vaccine.2011.07.019

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title = "Development of dengue DNA vaccines",

abstract = "Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine constructs and trials are underway to study these in the clinic. The scope of this review is to highlight the rich history of this vaccine platform and the work in dengue DNA vaccines accomplished by scientists at the Naval Medical Research Center. This work resulted in the only dengue DNA vaccine tested in a clinical trial to date. Additional advancements paving the road ahead in dengue DNA vaccine development are also discussed.",

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AU - Porter, Kevin R.

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AB - Vaccination with plasmid DNA against infectious pathogens including dengue is an active area of investigation. By design, DNA vaccines are able to elicit both antibody responses and cellular immune responses capable of mediating long-term protection. Great technical improvements have been made in dengue DNA vaccine constructs and trials are underway to study these in the clinic. The scope of this review is to highlight the rich history of this vaccine platform and the work in dengue DNA vaccines accomplished by scientists at the Naval Medical Research Center. This work resulted in the only dengue DNA vaccine tested in a clinical trial to date. Additional advancements paving the road ahead in dengue DNA vaccine development are also discussed.

KW - Clinical trials

KW - DNA vaccines

KW - Dengue

KW - Non-human primates

KW - Shuffled DNA vaccines

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Development of dengue DNA vaccines

Abstract

Keywords

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