TY - JOUR
T1 - Development of High-Throughput Mass Spectrometry-Based Approaches for Cancer Biomarker Discovery and Implementation
AU - Hood, Brian L.
AU - Stewart, Nicolas A.S.
AU - Conrads, Thomas P.
N1 - Funding Information:
This work was supported by funds from the Department of Defense (PC074313), the Hillman Foundation, and the David Scaife Foundation.
PY - 2009/3
Y1 - 2009/3
N2 - A major goal of cancer research is elucidating the molecular events underlying carcinogenesis, with the goal of discovering better diagnostic markers and therapeutic targets. Proteomics aims to facilitate this process by applying newly developed methods and advanced analytic tools, such as mass spectrometry, for the investigation of the protein complement en masse. Proteomics is the comprehensive study of proteins and is aimed at analyzing their structure, function, modifications, expression, interactions, and localization in complex biological systems. This article reviews the state-of-the art in mass spectrometry-based approaches and their application for cancer biomarker discovery and validation.
AB - A major goal of cancer research is elucidating the molecular events underlying carcinogenesis, with the goal of discovering better diagnostic markers and therapeutic targets. Proteomics aims to facilitate this process by applying newly developed methods and advanced analytic tools, such as mass spectrometry, for the investigation of the protein complement en masse. Proteomics is the comprehensive study of proteins and is aimed at analyzing their structure, function, modifications, expression, interactions, and localization in complex biological systems. This article reviews the state-of-the art in mass spectrometry-based approaches and their application for cancer biomarker discovery and validation.
KW - Biomarker
KW - Discovery
KW - Mass spectrometry
KW - Proteomics
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=64649084247&partnerID=8YFLogxK
U2 - 10.1016/j.cll.2009.01.007
DO - 10.1016/j.cll.2009.01.007
M3 - Review article
C2 - 19389555
AN - SCOPUS:64649084247
SN - 0272-2712
VL - 29
SP - 115
EP - 138
JO - Clinics in Laboratory Medicine
JF - Clinics in Laboratory Medicine
IS - 1
ER -