Development of nanoparticle-enabled protein biomarker discovery: Implementation for saliva-based traumatic brain injury detection

Shane V. Caswell; Nelson Cortes; Kelsey Mitchell; Lance Liotta; Emanuel F. Petricoin

doi:10.1007/978-3-662-45399-5_6

Development of nanoparticle-enabled protein biomarker discovery: Implementation for saliva-based traumatic brain injury detection

Shane V. Caswell^*, Nelson Cortes, Kelsey Mitchell, Lance Liotta, Emanuel F. Petricoin

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

In this chapter we will discuss a new approach for amplifying low-abundance proteins for biomarker discovery and how this new approach can be applied to identifying new markers for the detection of traumatic brain injury (TBI) and concussion. Of particular focus is the discovery of nonsubjective, sensitive, and specifi c biomarkers for early detection of TBI/concussion that can be quantifi ed accurately and which can be measured in an easily obtainable biofl uid. We propose that such a method can be applied to TBI detection in saliva-a biofl uid that heretofore has not been considered for this application.

Original language	English
Title of host publication	Advances in Salivary Diagnostics
Publisher	Springer Berlin Heidelberg
Pages	121-129
Number of pages	9
ISBN (Electronic)	9783662453995
ISBN (Print)	9783662453988
DOIs	https://doi.org/10.1007/978-3-662-45399-5_6
State	Published - 1 Jan 2015
Externally published	Yes

Keywords

Blood-brain barrier
Concussion
Mass spectrometry (MS)
Nanoparticles
Protein biomarker
Proteomics
Saliva
Traumatic brain injury

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10.1007/978-3-662-45399-5_6

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abstract = "In this chapter we will discuss a new approach for amplifying low-abundance proteins for biomarker discovery and how this new approach can be applied to identifying new markers for the detection of traumatic brain injury (TBI) and concussion. Of particular focus is the discovery of nonsubjective, sensitive, and specifi c biomarkers for early detection of TBI/concussion that can be quantifi ed accurately and which can be measured in an easily obtainable biofl uid. We propose that such a method can be applied to TBI detection in saliva-a biofl uid that heretofore has not been considered for this application.",

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AU - Cortes, Nelson

AU - Mitchell, Kelsey

AU - Liotta, Lance

AU - Petricoin, Emanuel F.

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KW - Concussion

KW - Mass spectrometry (MS)

KW - Nanoparticles

KW - Protein biomarker

KW - Proteomics

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Development of nanoparticle-enabled protein biomarker discovery: Implementation for saliva-based traumatic brain injury detection

Abstract

Keywords

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