Diagnosis and management of inhalation injury: An updated review

Patrick F. Walker; Michelle F. Buehner; Leslie A. Wood; Nathan L. Boyer; Ian R. Driscoll; Jonathan B. Lundy; Leopoldo C. Cancio; Kevin K. Chung

doi:10.1186/s13054-015-1077-4

Diagnosis and management of inhalation injury: An updated review

Patrick F. Walker, Michelle F. Buehner^*, Leslie A. Wood, Nathan L. Boyer, Ian R. Driscoll, Jonathan B. Lundy, Leopoldo C. Cancio, Kevin K. Chung

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

172 Scopus citations

Abstract

In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest computed tomography may allow for a more nuanced evaluation of inhalation injury and enhanced ability to prognosticate. Supportive respiratory care remains essential in managinginhalation injury. Adjuncts , lacking definitive evidence of efficacy include bronchodilators, mucolytic agents, inhaled anticoagulants, nonconventional ventilator modes, prone positioning, and extracorporeal membrane oxygenation. Recent research focusing on molecular mechanisms involved in inhalation injury has increased the number of potential therapies.

Original language	English
Article number	351
Journal	Critical Care
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13054-015-1077-4
State	Published - 28 Oct 2015
Externally published	Yes

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title = "Diagnosis and management of inhalation injury: An updated review",

abstract = "In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest computed tomography may allow for a more nuanced evaluation of inhalation injury and enhanced ability to prognosticate. Supportive respiratory care remains essential in managinginhalation injury. Adjuncts , lacking definitive evidence of efficacy include bronchodilators, mucolytic agents, inhaled anticoagulants, nonconventional ventilator modes, prone positioning, and extracorporeal membrane oxygenation. Recent research focusing on molecular mechanisms involved in inhalation injury has increased the number of potential therapies.",

author = "Walker, {Patrick F.} and Buehner, {Michelle F.} and Wood, {Leslie A.} and Boyer, {Nathan L.} and Driscoll, {Ian R.} and Lundy, {Jonathan B.} and Cancio, {Leopoldo C.} and Chung, {Kevin K.}",

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AU - Buehner, Michelle F.

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AU - Cancio, Leopoldo C.

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AB - In this article we review recent advances made in the pathophysiology, diagnosis, and treatment of inhalation injury. Historically, the diagnosis of inhalation injury has relied on nonspecific clinical exam findings and bronchoscopic evidence. The development of a grading system and the use of modalities such as chest computed tomography may allow for a more nuanced evaluation of inhalation injury and enhanced ability to prognosticate. Supportive respiratory care remains essential in managinginhalation injury. Adjuncts , lacking definitive evidence of efficacy include bronchodilators, mucolytic agents, inhaled anticoagulants, nonconventional ventilator modes, prone positioning, and extracorporeal membrane oxygenation. Recent research focusing on molecular mechanisms involved in inhalation injury has increased the number of potential therapies.

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Diagnosis and management of inhalation injury: An updated review

Abstract

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