Difference between the abilities of human Fcγ receptor-Expressing CV-1 cells to neutralize American and Asian Genotypes of dengue virus 2

W. W.I.S. Rodrigo; D. C. Alcena; Z. Kou; T. J. Kochel; K. R. Porter; G. Comach; R. C. Rose; X. Jin; J. J. Schlesinger

doi:10.1128/CVI.00363-08

Difference between the abilities of human Fcγ receptor-Expressing CV-1 cells to neutralize American and Asian Genotypes of dengue virus 2

W. W.I.S. Rodrigo, D. C. Alcena, Z. Kou, T. J. Kochel, K. R. Porter, G. Comach, R. C. Rose, X. Jin, J. J. Schlesinger

Medicine

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15 Scopus citations

Abstract

Sera from patients involved in a Peruvian outbreak of dengue virus serotype 1 infection cross-neutralized the American genotype of dengue virus serotype 2 up to 100-fold more efficiently than they did the virulent Asian genotype of dengue virus serotype 2, as determined by a plaque reduction neutralization test (PRNT) with CV-1 fibroblasts modified to express human Fcγ receptor CD32. The concordant preferential immune enhancement of the Asian genotype of dengue virus serotype 2 in human monocytes suggests that such a modification might strengthen the correlation between the PRNT titer and protection.

Original language	English
Pages (from-to)	285-287
Number of pages	3
Journal	Clinical and Vaccine Immunology
Volume	16
Issue number	2
DOIs	https://doi.org/10.1128/CVI.00363-08
State	Published - Feb 2009

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abstract = "Sera from patients involved in a Peruvian outbreak of dengue virus serotype 1 infection cross-neutralized the American genotype of dengue virus serotype 2 up to 100-fold more efficiently than they did the virulent Asian genotype of dengue virus serotype 2, as determined by a plaque reduction neutralization test (PRNT) with CV-1 fibroblasts modified to express human Fcγ receptor CD32. The concordant preferential immune enhancement of the Asian genotype of dengue virus serotype 2 in human monocytes suggests that such a modification might strengthen the correlation between the PRNT titer and protection.",

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AU - Rodrigo, W. W.I.S.

AU - Alcena, D. C.

AU - Kou, Z.

AU - Kochel, T. J.

AU - Porter, K. R.

AU - Comach, G.

AU - Rose, R. C.

AU - Jin, X.

AU - Schlesinger, J. J.

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AB - Sera from patients involved in a Peruvian outbreak of dengue virus serotype 1 infection cross-neutralized the American genotype of dengue virus serotype 2 up to 100-fold more efficiently than they did the virulent Asian genotype of dengue virus serotype 2, as determined by a plaque reduction neutralization test (PRNT) with CV-1 fibroblasts modified to express human Fcγ receptor CD32. The concordant preferential immune enhancement of the Asian genotype of dengue virus serotype 2 in human monocytes suggests that such a modification might strengthen the correlation between the PRNT titer and protection.

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Difference between the abilities of human Fcγ receptor-Expressing CV-1 cells to neutralize American and Asian Genotypes of dengue virus 2

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