@article{a0619bcfa23c4b89900c86d92c6e4768,
title = "Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG",
abstract = "The magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria require further characterization. A panel of 50 subtype G and 18 CRF02_AG Nigerian HIV-1 pseudoviruses (PSV) was developed and envelope coreceptor usage, neutralization sensitivity and cross-clade reactivity were characterized. These PSV were neutralized by some antibodies targeting major neutralizing determinants, but potentially important differences were observed in specific sensitivities (eg. to sCD4, MPER and V2/V3 monoclonal antibodies), as well as in properties such as variable loop lengths, number of potential N-linked glycans and charge, demonstrating distinct antigenic characteristics of CRF02_AG and subtype G. There was preferential neutralization of the matched CRF/subtype when PSV from subtype G or CRF02_AG were tested using pooled plasma. These novel Nigerian PSV will be useful to study HIV-1 CRF- or subtype-specific humoral immune responses for subtype G and CRF02_AG.",
keywords = "Antibody, CRF02_AG, Envelope (Env), HIV, Neutralization, Nigeria, Subtype G, West Africa",
author = "{on behalf of the AFRICOS and TRUST/RV368 Study Groups} and Lindsay Wieczorek and David Chang and Eric Sanders-Buell and Michelle Zemil and Elizabeth Martinez and Jesse Schoen and Chenine, {Agnes Laurence} and Sebastian Molnar and Brittani Barrows and Kultida Poltavee and Charurat, {Man E.} and Alash{\textquoteright}le Abimiku and William Blattner and Michael Iroezindu and Afoke Kokogho and Michael, {Nelson L.} and Crowell, {Trevor A.} and Ake, {Julie A.} and Sodsai Tovanabutra and Polonis, {Victoria R.} and Sandhya Vasan and Abdulwasiu Tiamiyu and Elizabeth Shoyemi and Cristina Rodriguez-Hart and Merlin Robb and Habib Ramadhani and Sheila Peel and Uchenna Ononaku and Rebecca Nowak and Jennifer Malia and Fengming Hu and Charlotte Gaydos and Stefan Baral and Sylvia Adebajo and Aka Abayomi and Manhattan Charurat and Willyhelmina Olomi and Peter Edwin and Hawa Mfumbulwa and Johnisius Msigwa and Gwamaka Mwaisanga and Paschal Kiliba and Nancy Somi and Doroth Mkondoo and Reginald Gervas and Mtasi Mwaipopo and Gloria David and Faraja Mbwayu and Jaquiline Mwamwaja and Abisai Kisinda",
note = "Publisher Copyright: {\textcopyright} This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024.",
year = "2024",
month = dec,
doi = "10.1186/s12985-024-02394-y",
language = "English",
volume = "21",
journal = "Virology Journal",
issn = "1743-422X",
publisher = "BioMed Central Ltd",
number = "1",
}