Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy

Christian Rosas-Salazar; Meghan H. Shilts; Andrey Tovchigrechko; Seth Schobel; James D. Chappell; Emma K. Larkin; Jyoti Shankar; Shibu Yooseph; Karen E. Nelson; Rebecca A. Halpin; Martin L. Moore; Larry J. Anderson; R. Stokes Peebles; Suman R. Das; Tina V. Hartert

doi:10.1093/infdis/jiw456

Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy

Christian Rosas-Salazar, Meghan H. Shilts, Andrey Tovchigrechko, Seth Schobel, James D. Chappell, Emma K. Larkin, Jyoti Shankar, Shibu Yooseph, Karen E. Nelson, Rebecca A. Halpin, Martin L. Moore, Larry J. Anderson, R. Stokes Peebles, Suman R. Das^*, Tina V. Hartert

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Respiratory viruses alter the nasopharyngeal microbiome and may be associated with a distinct microbial signature. To test this hypothesis, we compared the nasopharyngeal microbiome of 135 previously healthy infants with acute respiratory infection due to human rhinovirus (HRV; n = 52) or respiratory syncytial virus (RSV; n = 83). The nasopharyngeal microbiome was assessed by sequencing the V4 region of the 16S ribosomal RNA. Respiratory viruses were identified by quantitative reverse-transcription polymerase chain reaction.We found significant differences in the overall taxonomic composition and abundance of certain bacterial genera between infants infected with HRV and those infected with RSV. Our results suggest that respiratory tract viral infections are associated with different nasopharyngeal microbial profiles.

Original language	English
Pages (from-to)	1924-1928
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	214
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiw456
State	Published - 1 Dec 2016
Externally published	Yes

Keywords

Children
Human rhinovirus
Microbiome
Nasopharynx
Respiratory syncytial virus

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10.1093/infdis/jiw456

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Rosas-Salazar, C., Shilts, M. H., Tovchigrechko, A., Schobel, S., Chappell, J. D., Larkin, E. K., Shankar, J., Yooseph, S., Nelson, K. E., Halpin, R. A., Moore, M. L., Anderson, L. J., Peebles, R. S., Das, S. R., & Hartert, T. V. (2016). Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy. Journal of Infectious Diseases, 214(12), 1924-1928. https://doi.org/10.1093/infdis/jiw456

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title = "Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy",

abstract = "Respiratory viruses alter the nasopharyngeal microbiome and may be associated with a distinct microbial signature. To test this hypothesis, we compared the nasopharyngeal microbiome of 135 previously healthy infants with acute respiratory infection due to human rhinovirus (HRV; n = 52) or respiratory syncytial virus (RSV; n = 83). The nasopharyngeal microbiome was assessed by sequencing the V4 region of the 16S ribosomal RNA. Respiratory viruses were identified by quantitative reverse-transcription polymerase chain reaction.We found significant differences in the overall taxonomic composition and abundance of certain bacterial genera between infants infected with HRV and those infected with RSV. Our results suggest that respiratory tract viral infections are associated with different nasopharyngeal microbial profiles.",

keywords = "Children, Human rhinovirus, Microbiome, Nasopharynx, Respiratory syncytial virus",

author = "Christian Rosas-Salazar and Shilts, {Meghan H.} and Andrey Tovchigrechko and Seth Schobel and Chappell, {James D.} and Larkin, {Emma K.} and Jyoti Shankar and Shibu Yooseph and Nelson, {Karen E.} and Halpin, {Rebecca A.} and Moore, {Martin L.} and Anderson, {Larry J.} and Peebles, {R. Stokes} and Das, {Suman R.} and Hartert, {Tina V.}",

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doi = "10.1093/infdis/jiw456",

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Rosas-Salazar, C, Shilts, MH, Tovchigrechko, A, Schobel, S, Chappell, JD, Larkin, EK, Shankar, J, Yooseph, S, Nelson, KE, Halpin, RA, Moore, ML, Anderson, LJ, Peebles, RS, Das, SR & Hartert, TV 2016, 'Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy', Journal of Infectious Diseases, vol. 214, no. 12, pp. 1924-1928. https://doi.org/10.1093/infdis/jiw456

Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy. / Rosas-Salazar, Christian; Shilts, Meghan H.; Tovchigrechko, Andrey et al.
In: Journal of Infectious Diseases, Vol. 214, No. 12, 01.12.2016, p. 1924-1928.

Research output: Contribution to journal › Article › peer-review

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AU - Rosas-Salazar, Christian

AU - Shilts, Meghan H.

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AU - Chappell, James D.

AU - Larkin, Emma K.

AU - Shankar, Jyoti

AU - Yooseph, Shibu

AU - Nelson, Karen E.

AU - Halpin, Rebecca A.

AU - Moore, Martin L.

AU - Anderson, Larry J.

AU - Peebles, R. Stokes

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AB - Respiratory viruses alter the nasopharyngeal microbiome and may be associated with a distinct microbial signature. To test this hypothesis, we compared the nasopharyngeal microbiome of 135 previously healthy infants with acute respiratory infection due to human rhinovirus (HRV; n = 52) or respiratory syncytial virus (RSV; n = 83). The nasopharyngeal microbiome was assessed by sequencing the V4 region of the 16S ribosomal RNA. Respiratory viruses were identified by quantitative reverse-transcription polymerase chain reaction.We found significant differences in the overall taxonomic composition and abundance of certain bacterial genera between infants infected with HRV and those infected with RSV. Our results suggest that respiratory tract viral infections are associated with different nasopharyngeal microbial profiles.

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Differences in the nasopharyngeal microbiome during acute respiratory tract infection with human rhinovirus and respiratory syncytial virus in infancy

Abstract

Keywords

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