Differential loss of invariant natural killer T cells and FoxP3+ regulatory T cells in HIV-1 subtype A and subtype D infections

Britta Flach; Prossy Naluyima; Kim Blom; Veronica D. Gonzalez; Leigh Anne Eller; Oliver Laeyendecker; Thomas C. Quinn; David Serwadda; Nelson K. Sewankambo; Maria J. Wawer; Ronald H. Gray; Nelson L. Michael; Fred Wabwire-Mangen; Merlin L. Robb; Michael A. Eller; Johan K. Sandberg

doi:10.1097/QAI.0b013e31828b2073

Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections

Britta Flach, Prossy Naluyima, Kim Blom, Veronica D. Gonzalez, Leigh Anne Eller, Oliver Laeyendecker, Thomas C. Quinn, David Serwadda, Nelson K. Sewankambo, Maria J. Wawer, Ronald H. Gray, Nelson L. Michael, Fred Wabwire-Mangen, Merlin L. Robb, Michael A. Eller, Johan K. Sandberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3⁺ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.

Original language	English
Pages (from-to)	289-293
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	63
Issue number	3
DOIs	https://doi.org/10.1097/QAI.0b013e31828b2073
State	Published - 1 Jul 2013
Externally published	Yes

Keywords

AIDS
CD1d
HIV-1
INKT cell
T regulatory cell
Viral subtype

Access to Document

10.1097/QAI.0b013e31828b2073

Cite this

Flach, B., Naluyima, P., Blom, K., Gonzalez, V. D., Eller, L. A., Laeyendecker, O., Quinn, T. C., Serwadda, D., Sewankambo, N. K., Wawer, M. J., Gray, R. H., Michael, N. L., Wabwire-Mangen, F., Robb, M. L., Eller, M. A., & Sandberg, J. K. (2013). Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections. Journal of Acquired Immune Deficiency Syndromes, 63(3), 289-293. https://doi.org/10.1097/QAI.0b013e31828b2073

@article{b251dc8d65c04c7781ead1e76bbda2c1,

title = "Differential loss of invariant natural killer T cells and FoxP3+ regulatory T cells in HIV-1 subtype A and subtype D infections",

abstract = "HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3+ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.",

keywords = "AIDS, CD1d, HIV-1, INKT cell, T regulatory cell, Viral subtype",

author = "Britta Flach and Prossy Naluyima and Kim Blom and Gonzalez, {Veronica D.} and Eller, {Leigh Anne} and Oliver Laeyendecker and Quinn, {Thomas C.} and David Serwadda and Sewankambo, {Nelson K.} and Wawer, {Maria J.} and Gray, {Ronald H.} and Michael, {Nelson L.} and Fred Wabwire-Mangen and Robb, {Merlin L.} and Eller, {Michael A.} and Sandberg, {Johan K.}",

year = "2013",

month = jul,

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doi = "10.1097/QAI.0b013e31828b2073",

language = "English",

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pages = "289--293",

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Flach, B, Naluyima, P, Blom, K, Gonzalez, VD, Eller, LA, Laeyendecker, O, Quinn, TC, Serwadda, D, Sewankambo, NK, Wawer, MJ, Gray, RH, Michael, NL, Wabwire-Mangen, F, Robb, ML, Eller, MA & Sandberg, JK 2013, 'Differential loss of invariant natural killer T cells and FoxP3⁺ regulatory T cells in HIV-1 subtype A and subtype D infections', Journal of Acquired Immune Deficiency Syndromes, vol. 63, no. 3, pp. 289-293. https://doi.org/10.1097/QAI.0b013e31828b2073

TY - JOUR

T1 - Differential loss of invariant natural killer T cells and FoxP3+ regulatory T cells in HIV-1 subtype A and subtype D infections

AU - Flach, Britta

AU - Naluyima, Prossy

AU - Blom, Kim

AU - Gonzalez, Veronica D.

AU - Eller, Leigh Anne

AU - Laeyendecker, Oliver

AU - Quinn, Thomas C.

AU - Serwadda, David

AU - Sewankambo, Nelson K.

AU - Wawer, Maria J.

AU - Gray, Ronald H.

AU - Michael, Nelson L.

AU - Wabwire-Mangen, Fred

AU - Robb, Merlin L.

AU - Eller, Michael A.

AU - Sandberg, Johan K.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3+ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.

AB - HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3+ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.

KW - AIDS

KW - CD1d

KW - HIV-1

KW - INKT cell

KW - T regulatory cell

KW - Viral subtype

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DO - 10.1097/QAI.0b013e31828b2073

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AN - SCOPUS:84880247221

SN - 1525-4135

VL - 63

SP - 289

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JO - Journal of Acquired Immune Deficiency Syndromes

JF - Journal of Acquired Immune Deficiency Syndromes

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