Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus

Jason W. Bennett; Clinton K. Murray; Robert L. Holmes; Jan E. Patterson; James H. Jorgensen

doi:10.1016/j.diagmicrobio.2007.11.002

Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus

Jason W. Bennett^*, Clinton K. Murray, Robert L. Holmes, Jan E. Patterson, James H. Jorgensen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy.

Original language	English
Pages (from-to)	437-440
Number of pages	4
Journal	Diagnostic Microbiology and Infectious Disease
Volume	60
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2007.11.002
State	Published - Apr 2008

Keywords

Bactericidal effect
Daptomycin resistance
Minimum inhibitory concentration
MRSA bacteremia
Vancomycin tolerance

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10.1016/j.diagmicrobio.2007.11.002

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title = "Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus",

abstract = "An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy.",

keywords = "Bactericidal effect, Daptomycin resistance, Minimum inhibitory concentration, MRSA bacteremia, Vancomycin tolerance",

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AU - Murray, Clinton K.

AU - Holmes, Robert L.

AU - Patterson, Jan E.

AU - Jorgensen, James H.

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AB - An elderly patient with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was treated sequentially with vancomycin plus rifampin then daptomycin plus gentamicin. The MRSA strain developed diminished susceptibility to vancomycin (MIC increase and tolerance), daptomycin, and gentamicin, and resistance to rifampin during therapy.

KW - Bactericidal effect

KW - Daptomycin resistance

KW - Minimum inhibitory concentration

KW - MRSA bacteremia

KW - Vancomycin tolerance

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ER -

Diminished vancomycin and daptomycin susceptibility during prolonged bacteremia with methicillin-resistant Staphylococcus aureus

Abstract

Keywords

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