Disorders of localized inflammation in wound healing

David G. Nascari; Raphael J. Crum; Stephen F. Badylak

doi:10.1007/978-3-030-56510-7_10

Disorders of localized inflammation in wound healing

David G. Nascari, Raphael J. Crum, Stephen F. Badylak^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Wound healing is a conserved, multistep physiological process that relies on a balanced equilibrium between neutralization of the causative agent and restoration of native tissue structure and function. An imbalance at any step can quickly escalate into a dysregulated positive feedback loop, resulting in chronic inflammation, loss of function, or tissue death. Failures or dysregulation of these steps can result in phenotypes of aberrant wound healing that eventually manifest as chronic inflammation. This approach to physiological and pathological wound healing will be explored from a combined systems and molecular biology perspective with relevance to the clinical setting.

Original language	English
Title of host publication	Complex Systems and Computational Biology Approaches to Acute Inflammation
Subtitle of host publication	A Framework for Model-based Precision Medicine
Publisher	Springer International Publishing
Pages	185-198
Number of pages	14
ISBN (Electronic)	9783030565107
ISBN (Print)	9783030565091
DOIs	https://doi.org/10.1007/978-3-030-56510-7_10
State	Published - 4 Nov 2020
Externally published	Yes

Keywords

Angiogenesis
Epithelialization
Extracellular matrix
Hemostasis
Immunomodulation
Inflammation
Tissue repair
Wound healing

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10.1007/978-3-030-56510-7_10

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Disorders of localized inflammation in wound healing. / Nascari, David G.; Crum, Raphael J.; Badylak, Stephen F.
Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine. Springer International Publishing, 2020. p. 185-198.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AU - Crum, Raphael J.

AU - Badylak, Stephen F.

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Y1 - 2020/11/4

N2 - Wound healing is a conserved, multistep physiological process that relies on a balanced equilibrium between neutralization of the causative agent and restoration of native tissue structure and function. An imbalance at any step can quickly escalate into a dysregulated positive feedback loop, resulting in chronic inflammation, loss of function, or tissue death. Failures or dysregulation of these steps can result in phenotypes of aberrant wound healing that eventually manifest as chronic inflammation. This approach to physiological and pathological wound healing will be explored from a combined systems and molecular biology perspective with relevance to the clinical setting.

AB - Wound healing is a conserved, multistep physiological process that relies on a balanced equilibrium between neutralization of the causative agent and restoration of native tissue structure and function. An imbalance at any step can quickly escalate into a dysregulated positive feedback loop, resulting in chronic inflammation, loss of function, or tissue death. Failures or dysregulation of these steps can result in phenotypes of aberrant wound healing that eventually manifest as chronic inflammation. This approach to physiological and pathological wound healing will be explored from a combined systems and molecular biology perspective with relevance to the clinical setting.

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KW - Epithelialization

KW - Extracellular matrix

KW - Hemostasis

KW - Immunomodulation

KW - Inflammation

KW - Tissue repair

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Disorders of localized inflammation in wound healing

Abstract

Keywords

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