Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Elizabeth M. Terrell; David E. Durrant; Daniel A. Ritt; Nancy E. Sealover; Erin Sheffels; Russell Spencer-Smith; Dominic Esposito; Yong Zhou; John F. Hancock; Robert L. Kortum; Deborah K. Morrison

doi:10.1016/j.molcel.2019.09.004

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Elizabeth M. Terrell
, David E. Durrant
, Daniel A. Ritt
, Nancy E. Sealover
, Erin Sheffels
, Russell Spencer-Smith
, Dominic Esposito
, Yong Zhou
, John F. Hancock
, Robert L. Kortum
, Deborah K. Morrison^*

^*Corresponding author for this work

Pharmacology and Molecular Therapeutics

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

The Raf kinases bind to active Ras proteins and function to transmit signals that control cell growth and tumorigenesis. The study by Terrell et al. reveals distinct binding preferences between individual Ras and Raf family members and identifies events that can alter these interactions to upregulate Ras-driven cancer signaling.

Original language	English
Pages (from-to)	872-884.e5
Journal	Molecular Cell
Volume	76
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2019.09.004
State	Published - 19 Dec 2019

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title = "Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling",

abstract = "The Raf kinases bind to active Ras proteins and function to transmit signals that control cell growth and tumorigenesis. The study by Terrell et al. reveals distinct binding preferences between individual Ras and Raf family members and identifies events that can alter these interactions to upregulate Ras-driven cancer signaling.",

author = "Terrell, \{Elizabeth M.\} and Durrant, \{David E.\} and Ritt, \{Daniel A.\} and Sealover, \{Nancy E.\} and Erin Sheffels and Russell Spencer-Smith and Dominic Esposito and Yong Zhou and Hancock, \{John F.\} and Kortum, \{Robert L.\} and Morrison, \{Deborah K.\}",

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doi = "10.1016/j.molcel.2019.09.004",

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AU - Terrell, Elizabeth M.

AU - Durrant, David E.

AU - Ritt, Daniel A.

AU - Sealover, Nancy E.

AU - Sheffels, Erin

AU - Spencer-Smith, Russell

AU - Esposito, Dominic

AU - Zhou, Yong

AU - Hancock, John F.

AU - Kortum, Robert L.

AU - Morrison, Deborah K.

PY - 2019/12/19

Y1 - 2019/12/19

N2 - The Raf kinases bind to active Ras proteins and function to transmit signals that control cell growth and tumorigenesis. The study by Terrell et al. reveals distinct binding preferences between individual Ras and Raf family members and identifies events that can alter these interactions to upregulate Ras-driven cancer signaling.

AB - The Raf kinases bind to active Ras proteins and function to transmit signals that control cell growth and tumorigenesis. The study by Terrell et al. reveals distinct binding preferences between individual Ras and Raf family members and identifies events that can alter these interactions to upregulate Ras-driven cancer signaling.

UR - https://www.scopus.com/pages/publications/85075151565

U2 - 10.1016/j.molcel.2019.09.004

DO - 10.1016/j.molcel.2019.09.004

M3 - Article

C2 - 31606273

AN - SCOPUS:85075151565

SN - 1097-2765

VL - 76

SP - 872-884.e5

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

Abstract

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