Docosahexaenoic acid (22:6n3)-induced relaxation of the rat aorta

Mary B. Engler; John W. Karanian; Norman Salem

doi:10.1016/0014-2999(90)90644-L

Docosahexaenoic acid (22:6n3)-induced relaxation of the rat aorta

Mary B. Engler^*, John W. Karanian, Norman Salem

^*Corresponding author for this work

Graduate School of Nursing

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Dietary consumption of fish and fish oil supplements, containing eicosapentaenoic acid and docosahexaenoic acid, has been associated with favorable alterations in the cardiovascular system, such as, a reduction in blood pressure. Therefore, the effects of docosahexaenoic acid (22:6n3) on isometric tension of rat aortic smooth muscle were investigated. A concentration-dependent (1-127 μM) relaxation (6-30%) was induced by 22:6n3 in non-precontracted vessels. Docosaehexaenoic acid, concentration dependently (1-44 μM) reversed contractions of rat aortic rings induced by phenylephrine (7-43%) and by U44069 (8-52%). These results indicate that the relaxant effects produced by 22 : 6n3 in the rat aorta are concentration-dependent and not specific to the contractile agonist.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	European Journal of Pharmacology
Volume	185
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(90)90644-L
State	Published - 28 Aug 1990

Keywords

(Fish oils)
Cardiovascular disease
Docosahexaenoic acid
Fatty acids (n-3 polyunsaturated)
Vascular responses
ω-Fatty acids

Access to Document

10.1016/0014-2999(90)90644-L

Cite this

@article{e63e193b409a4fdd9a2e35cc73f52ae0,

title = "Docosahexaenoic acid (22:6n3)-induced relaxation of the rat aorta",

abstract = "Dietary consumption of fish and fish oil supplements, containing eicosapentaenoic acid and docosahexaenoic acid, has been associated with favorable alterations in the cardiovascular system, such as, a reduction in blood pressure. Therefore, the effects of docosahexaenoic acid (22:6n3) on isometric tension of rat aortic smooth muscle were investigated. A concentration-dependent (1-127 μM) relaxation (6-30%) was induced by 22:6n3 in non-precontracted vessels. Docosaehexaenoic acid, concentration dependently (1-44 μM) reversed contractions of rat aortic rings induced by phenylephrine (7-43%) and by U44069 (8-52%). These results indicate that the relaxant effects produced by 22 : 6n3 in the rat aorta are concentration-dependent and not specific to the contractile agonist.",

keywords = "(Fish oils), Cardiovascular disease, Docosahexaenoic acid, Fatty acids (n-3 polyunsaturated), Vascular responses, ω-Fatty acids",

author = "Engler, {Mary B.} and Karanian, {John W.} and Norman Salem",

year = "1990",

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T1 - Docosahexaenoic acid (22:6n3)-induced relaxation of the rat aorta

AU - Engler, Mary B.

AU - Karanian, John W.

AU - Salem, Norman

PY - 1990/8/28

Y1 - 1990/8/28

N2 - Dietary consumption of fish and fish oil supplements, containing eicosapentaenoic acid and docosahexaenoic acid, has been associated with favorable alterations in the cardiovascular system, such as, a reduction in blood pressure. Therefore, the effects of docosahexaenoic acid (22:6n3) on isometric tension of rat aortic smooth muscle were investigated. A concentration-dependent (1-127 μM) relaxation (6-30%) was induced by 22:6n3 in non-precontracted vessels. Docosaehexaenoic acid, concentration dependently (1-44 μM) reversed contractions of rat aortic rings induced by phenylephrine (7-43%) and by U44069 (8-52%). These results indicate that the relaxant effects produced by 22 : 6n3 in the rat aorta are concentration-dependent and not specific to the contractile agonist.

AB - Dietary consumption of fish and fish oil supplements, containing eicosapentaenoic acid and docosahexaenoic acid, has been associated with favorable alterations in the cardiovascular system, such as, a reduction in blood pressure. Therefore, the effects of docosahexaenoic acid (22:6n3) on isometric tension of rat aortic smooth muscle were investigated. A concentration-dependent (1-127 μM) relaxation (6-30%) was induced by 22:6n3 in non-precontracted vessels. Docosaehexaenoic acid, concentration dependently (1-44 μM) reversed contractions of rat aortic rings induced by phenylephrine (7-43%) and by U44069 (8-52%). These results indicate that the relaxant effects produced by 22 : 6n3 in the rat aorta are concentration-dependent and not specific to the contractile agonist.

KW - (Fish oils)

KW - Cardiovascular disease

KW - Docosahexaenoic acid

KW - Fatty acids (n-3 polyunsaturated)

KW - Vascular responses

KW - ω-Fatty acids

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