Doppler Ultrasonic Detection of Particulate Release During Hemodialysis with Cellulose Hollow‐Fiber and Sorbent Suspension Reciprocating Dialyzers

Stephen F. Badylak*, Stephen R. Ash, Jerry A. Thornhill, David J. Carr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Abstract: Doppler ultrasound is a noninvasive technique for monitoring moving objects such as flowing blood while ignoring stationary objects such as shunt tubing. A Doppler system was investigated to determine its sensitivity in detecting particulate release in blood during hemodialysis. Seven hemodialysis procedures with dogs and six trials with humans were done using a sorbent suspension reciprocating dialyzer (SSRD). Two additional trials were done with humans using a cellulose acetate hollow‐fiber dialyzer (HFD). A large increase (approximately twofold) was found in the reflected Doppler signal in outflowing blood from the SSRD and HFD in both dogs and humans. Numerous additional studies to characterize the nature of the particulate matter showed platelet aggregates in the dogs and fibrinogen‐fibrin degradation products in the humans to be present in the outflowing blood. In vitro studies suggested microscopic air bubbles (<25μm in diameter) may have contributed to the particulate matter detected during hemodialysis by this sensitive monitoring system.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalArtificial Organs
Volume8
Issue number2
DOIs
StatePublished - May 1984
Externally publishedYes

Keywords

  • Doppler ultrasound
  • Extracorporeal circulation
  • Hemodialysis
  • Particulate release

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