@article{e1d1a0ed30394767be96756ca3ba7838,
title = "Dose response of sodium nitrite on vasoactivity associated with HBOC-201 in a swine model of controlled hemorrhage",
abstract = "Sodium nitrite (NaNO 2) was evaluated in a 55% EBV hemorrhage swine model to mitigate the increased blood pressure due to HBOC-201. Animals were resuscitated by three 10ml/kg infusions of either HBOC-201 or Hextend with and without NaNO 2. All vital signs, coagulation and blood chemistry were measured for 2hr. HBOC-201-vasoconstriction was attenuated only after the first 10.8μmol/kg NaNO 2 infusion. Complete abolition was obtained with the highest 3 NaNO 2 dose, but side effects were observed. There was no reduction in platelet function due to NaNO 2. NaNO 2 ability to reduce HBOC-201 vasoactivity was transient and 10.8μmol/kg NaNO 2 seems an acceptable dose for further investigation.",
keywords = "Blood pressure, Nitric oxide donors, Pre-clinical resuscitation, Trauma",
author = "Fran{\c c}oise Arnaud and Scultetus, {Anke H.} and Bobby Kim and Ashraful Haque and Biswajit Saha and Savita Nigam and Paula Moon-Massat and Charles Auker and Richard McCarron and Daniel Freilich",
note = "Funding Information: Corresponding author: Fran {\c c} oise Arnaud, PhD. Naval Medical Research Center (NMRC). Operational and Undersea Medicine. NeuroTrauma Department. 503 Robert Grant Ave. Silver Spring, Maryland 20910-7500. E-mail:
[email protected] Disclaimer: This work has been performed at the naval Medical Research Center and was supported and funded by work unit number BUMED congressionally funded work unit #604771N.9737.001.A0315. CAPT. Freilich is a military service member (or employee of the U.S. Government). This work was prepared as part of his official duties. Title 17 U.S.C. 105 provides that {\textquoteleft} Copyright protection under this title is not available for any work of the United States Government.{\textquoteright} Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person {\textquoteright}s official duties. Funding Information: This work was supported by congressionally funded work unit #604771N.9737.001.A0315. CAPT. Freilich is a military service member (or employee of the U.S. Government). This work was prepared as part of his official duties. Title 17 U.S.C. § 105 provides that {\textquoteleft} Copyright protection under this title is not available for any work of the United States Government.{\textquoteright} Title 17 U.S.C. 101 defines a U.S. Government work as a work prepared by a military service member or employee of the U.S. Government as part of that person s official duties.",
year = "2011",
month = aug,
doi = "10.3109/10731199.2010.533126",
language = "English",
volume = "39",
pages = "195--205",
journal = "Artificial Cells, Blood Substitutes, and Biotechnology",
issn = "1073-1199",
number = "4",
}