TY - JOUR
T1 - Driving CARs to BARs
T2 - The Winding Road to Specific Regulatory T Cells for Tolerance
AU - Scott, David W.
N1 - Publisher Copyright:
© Copyright © 2021 Scott.
PY - 2021/9/6
Y1 - 2021/9/6
N2 - Chimeric antigen receptor (CAR) transduced T cells have significantly improved cancer immunotherapy. Similarly, engineering regulatory T cells (Treg) with specific receptors to endow specificity and increase efficacy of Tregs holds great promise for therapy of a variety of adverse immune responses. In this review, we focus on our approaches using retroviral transduction of specific T-cell receptors, single chain variable fragments (scFv) or antigen in models of monogenic diseases, autoimmunity and allergy. The advantages of each of these for different targets diseases are discussed as well as their potential for clinical translation.
AB - Chimeric antigen receptor (CAR) transduced T cells have significantly improved cancer immunotherapy. Similarly, engineering regulatory T cells (Treg) with specific receptors to endow specificity and increase efficacy of Tregs holds great promise for therapy of a variety of adverse immune responses. In this review, we focus on our approaches using retroviral transduction of specific T-cell receptors, single chain variable fragments (scFv) or antigen in models of monogenic diseases, autoimmunity and allergy. The advantages of each of these for different targets diseases are discussed as well as their potential for clinical translation.
KW - EAE (experimental autoimmune encephalitis)
KW - allergy
KW - autoimmunity
KW - chimeric antigen receptor
KW - hemophilia
KW - regulatory T cell (Treg)
KW - tolerance
UR - http://www.scopus.com/inward/record.url?scp=85115131567&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.742719
DO - 10.3389/fimmu.2021.742719
M3 - Review article
C2 - 34552599
AN - SCOPUS:85115131567
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 742719
ER -