Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

Eric D. Laing; Carol D. Weiss; Emily C. Samuels; Si'Ana A. Coggins; Wei Wang; Richard Wang; Russell Vassell; Spencer L. Sterling; Marana S. Tso; Tonia Conner; Emilie Goguet; Matthew Moser; Belinda M. Jackson-Thompson; Luca Illinik; Julian Davies; Orlando Ortega; Edward Parmelee; Monique Hollis-Perry; Santina E. Maiolatesi; Gregory Wang; Kathleen F. Ramsey; Anatalio E. Reyes; Yolanda Alcorta; Mimi A. Wong; Alyssa R. Lindrose; Christopher A. Duplessis; David R. Tribble; Allison M.W. Malloy; Timothy H. Burgess; Simon D. Pollett; Cara H. Olsen; Christopher C. Broder; Edward Mitre

doi:10.3201/eid2804.212037

Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

Eric D. Laing, Carol D. Weiss, Emily C. Samuels, Si'Ana A. Coggins, Wei Wang, Richard Wang, Russell Vassell, Spencer L. Sterling, Marana S. Tso, Tonia Conner, Emilie Goguet, Matthew Moser, Belinda M. Jackson-Thompson, Luca Illinik, Julian Davies, Orlando Ortega, Edward Parmelee, Monique Hollis-Perry, Santina E. Maiolatesi, Gregory WangKathleen F. Ramsey, Anatalio E. Reyes, Yolanda Alcorta, Mimi A. Wong, Alyssa R. Lindrose, Christopher A. Duplessis, David R. Tribble, Allison M.W. Malloy, Timothy H. Burgess, Simon D. Pollett, Cara H. Olsen, Christopher C. Broder, Edward Mitre^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.

Original language	English
Pages (from-to)	828-832
Number of pages	5
Journal	Emerging Infectious Diseases
Volume	28
Issue number	4
DOIs	https://doi.org/10.3201/eid2804.212037
State	Published - Apr 2022
Externally published	Yes

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Laing, E. D., Weiss, C. D., Samuels, E. C., Coggins, SA. A., Wang, W., Wang, R., Vassell, R., Sterling, S. L., Tso, M. S., Conner, T., Goguet, E., Moser, M., Jackson-Thompson, B. M., Illinik, L., Davies, J., Ortega, O., Parmelee, E., Hollis-Perry, M., Maiolatesi, S. E., ... Mitre, E. (2022). Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers. Emerging Infectious Diseases, 28(4), 828-832. https://doi.org/10.3201/eid2804.212037

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title = "Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.",

author = "Laing, {Eric D.} and Weiss, {Carol D.} and Samuels, {Emily C.} and Coggins, {Si'Ana A.} and Wei Wang and Richard Wang and Russell Vassell and Sterling, {Spencer L.} and Tso, {Marana S.} and Tonia Conner and Emilie Goguet and Matthew Moser and Jackson-Thompson, {Belinda M.} and Luca Illinik and Julian Davies and Orlando Ortega and Edward Parmelee and Monique Hollis-Perry and Maiolatesi, {Santina E.} and Gregory Wang and Ramsey, {Kathleen F.} and Reyes, {Anatalio E.} and Yolanda Alcorta and Wong, {Mimi A.} and Lindrose, {Alyssa R.} and Duplessis, {Christopher A.} and Tribble, {David R.} and Malloy, {Allison M.W.} and Burgess, {Timothy H.} and Pollett, {Simon D.} and Olsen, {Cara H.} and Broder, {Christopher C.} and Edward Mitre",

year = "2022",

month = apr,

doi = "10.3201/eid2804.212037",

language = "English",

volume = "28",

pages = "828--832",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

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Laing, ED, Weiss, CD, Samuels, EC, Coggins, SAA, Wang, W, Wang, R, Vassell, R, Sterling, SL, Tso, MS, Conner, T, Goguet, E, Moser, M, Jackson-Thompson, BM, Illinik, L, Davies, J, Ortega, O, Parmelee, E, Hollis-Perry, M, Maiolatesi, SE, Wang, G, Ramsey, KF, Reyes, AE, Alcorta, Y, Wong, MA, Lindrose, AR, Duplessis, CA, Tribble, DR, Malloy, AMW, Burgess, TH , Pollett, SD , Olsen, CH, Broder, CC & Mitre, E 2022, 'Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers', Emerging Infectious Diseases, vol. 28, no. 4, pp. 828-832. https://doi.org/10.3201/eid2804.212037

TY - JOUR

T1 - Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

AU - Laing, Eric D.

AU - Weiss, Carol D.

AU - Samuels, Emily C.

AU - Coggins, Si'Ana A.

AU - Wang, Wei

AU - Wang, Richard

AU - Vassell, Russell

AU - Sterling, Spencer L.

AU - Tso, Marana S.

AU - Conner, Tonia

AU - Goguet, Emilie

AU - Moser, Matthew

AU - Jackson-Thompson, Belinda M.

AU - Illinik, Luca

AU - Davies, Julian

AU - Ortega, Orlando

AU - Parmelee, Edward

AU - Hollis-Perry, Monique

AU - Maiolatesi, Santina E.

AU - Wang, Gregory

AU - Ramsey, Kathleen F.

AU - Reyes, Anatalio E.

AU - Alcorta, Yolanda

AU - Wong, Mimi A.

AU - Lindrose, Alyssa R.

AU - Duplessis, Christopher A.

AU - Tribble, David R.

AU - Malloy, Allison M.W.

AU - Burgess, Timothy H.

AU - Pollett, Simon D.

AU - Olsen, Cara H.

AU - Broder, Christopher C.

AU - Mitre, Edward

PY - 2022/4

Y1 - 2022/4

N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.

AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies decay but persist 6 months postvaccination; lower levels of neutralizing titers persist against Delta than wild-type virus. Of 227 vaccinated healthcare workers tested, only 2 experienced outpatient symptomatic breakthrough infections, despite 59/227 exhibiting serologic evidence of SARS-CoV-2 infection, defined as presence of nucleocapsid protein antibodies.

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U2 - 10.3201/eid2804.212037

DO - 10.3201/eid2804.212037

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AN - SCOPUS:85127183262

SN - 1080-6040

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SP - 828

EP - 832

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 4

ER -

Durability of Antibody Response and Frequency of SARS-CoV-2 Infection 6 Months after COVID-19 Vaccination in Healthcare Workers

Abstract

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