Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection

Kerri G. Lal; Dohoon Kim; Margaret C. Costanzo; Matthew Creegan; Edwin Leeansyah; Joana Dias; Dominic Paquin-Proulx; Leigh Anne Eller; Alexandra Schuetz; Yuwadee Phuang-ngern; Shelly J. Krebs; Bonnie M. Slike; Hannah Kibuuka; Lucas Maganga; Sorachai Nitayaphan; Josphat Kosgei; Carlo Sacdalan; Jintanat Ananworanich; Diane L. Bolton; Nelson L. Michael; Barbara L. Shacklett; Merlin L. Robb; Michael A. Eller; Johan K. Sandberg

doi:10.1038/s41467-019-13975-9

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection

Kerri G. Lal
, Dohoon Kim
, Margaret C. Costanzo
, Matthew Creegan
, Edwin Leeansyah
, Joana Dias
, Dominic Paquin-Proulx
, Leigh Anne Eller
, Alexandra Schuetz
, Yuwadee Phuang-ngern
, Shelly J. Krebs
, Bonnie M. Slike
, Hannah Kibuuka
, Lucas Maganga
, Sorachai Nitayaphan
, Josphat Kosgei
, Carlo Sacdalan
, Jintanat Ananworanich
, Diane L. Bolton
, Nelson L. Michael

Barbara L. Shacklett, Merlin L. Robb, Michael A. Eller, Johan K. Sandberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.

Original language	English
Article number	272
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-13975-9
State	Published - 1 Dec 2020

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Lal, K. G., Kim, D., Costanzo, M. C., Creegan, M., Leeansyah, E., Dias, J., Paquin-Proulx, D., Eller, L. A., Schuetz, A., Phuang-ngern, Y., Krebs, S. J., Slike, B. M., Kibuuka, H., Maganga, L., Nitayaphan, S., Kosgei, J., Sacdalan, C., Ananworanich, J., Bolton, D. L., ... Sandberg, J. K. (2020). Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection. Nature Communications, 11(1), Article 272. https://doi.org/10.1038/s41467-019-13975-9

@article{2c017ba82cea47eb821ebc66e51e2321,

title = "Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection",

abstract = "Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.",

author = "Lal, \{Kerri G.\} and Dohoon Kim and Costanzo, \{Margaret C.\} and Matthew Creegan and Edwin Leeansyah and Joana Dias and Dominic Paquin-Proulx and Eller, \{Leigh Anne\} and Alexandra Schuetz and Yuwadee Phuang-ngern and Krebs, \{Shelly J.\} and Slike, \{Bonnie M.\} and Hannah Kibuuka and Lucas Maganga and Sorachai Nitayaphan and Josphat Kosgei and Carlo Sacdalan and Jintanat Ananworanich and Bolton, \{Diane L.\} and Michael, \{Nelson L.\} and Shacklett, \{Barbara L.\} and Robb, \{Merlin L.\} and Eller, \{Michael A.\} and Sandberg, \{Johan K.\}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s41467-019-13975-9",

language = "English",

volume = "11",

journal = "Nature Communications",

issn = "2041-1723",

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Lal, KG, Kim, D, Costanzo, MC, Creegan, M, Leeansyah, E, Dias, J, Paquin-Proulx, D, Eller, LA, Schuetz, A, Phuang-ngern, Y, Krebs, SJ, Slike, BM, Kibuuka, H, Maganga, L, Nitayaphan, S, Kosgei, J, Sacdalan, C, Ananworanich, J, Bolton, DL, Michael, NL, Shacklett, BL, Robb, ML, Eller, MA & Sandberg, JK 2020, 'Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection', Nature Communications, vol. 11, no. 1, 272. https://doi.org/10.1038/s41467-019-13975-9

TY - JOUR

T1 - Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection

AU - Lal, Kerri G.

AU - Kim, Dohoon

AU - Costanzo, Margaret C.

AU - Creegan, Matthew

AU - Leeansyah, Edwin

AU - Dias, Joana

AU - Paquin-Proulx, Dominic

AU - Eller, Leigh Anne

AU - Schuetz, Alexandra

AU - Phuang-ngern, Yuwadee

AU - Krebs, Shelly J.

AU - Slike, Bonnie M.

AU - Kibuuka, Hannah

AU - Maganga, Lucas

AU - Nitayaphan, Sorachai

AU - Kosgei, Josphat

AU - Sacdalan, Carlo

AU - Ananworanich, Jintanat

AU - Bolton, Diane L.

AU - Michael, Nelson L.

AU - Shacklett, Barbara L.

AU - Robb, Merlin L.

AU - Eller, Michael A.

AU - Sandberg, Johan K.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.

AB - Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.

UR - https://www.scopus.com/pages/publications/85077844981

U2 - 10.1038/s41467-019-13975-9

DO - 10.1038/s41467-019-13975-9

M3 - Article

C2 - 31937782

AN - SCOPUS:85077844981

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 272

ER -

Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection

Abstract

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