TY - JOUR
T1 - Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection
AU - on behalf of the RV254/ SEARCH010 Study Group
AU - Song, Hongshuo
AU - Bose, Meera
AU - Pinyakorn, Suteeraporn
AU - Sanders-Buell, Eric
AU - O’Sullivan, Anne Marie
AU - Silas, Daniel
AU - Trichavaroj, Rapee
AU - Nuntapinit, Bessara
AU - Pham, Phuc T.
AU - Akapirat, Siriwat
AU - Kroon, Eugène
AU - de Souza, Mark
AU - Gramzinski, Robert
AU - Michael, Nelson L.
AU - Robb, Merlin L.
AU - Vasan, Sandhya
AU - Tovanabutra, Sodsai
AU - Ananworanich, Jintanat
N1 - Publisher Copyright:
© The Author(s) 2020.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
AB - We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
KW - Acute HIV infection
KW - Fiebig stage
KW - Genetic diversity
KW - HIV
UR - http://www.scopus.com/inward/record.url?scp=85096713723&partnerID=8YFLogxK
U2 - 10.1093/ofid/ofaa429
DO - 10.1093/ofid/ofaa429
M3 - Article
AN - SCOPUS:85096713723
SN - 2328-8957
VL - 7
SP - 1
EP - 4
JO - Open Forum Infectious Diseases
JF - Open Forum Infectious Diseases
IS - 10
ER -