Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection

on behalf of the RV254/ SEARCH010 Study Group

doi:10.1093/ofid/ofaa429

Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection

on behalf of the RV254/ SEARCH010 Study Group

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Open Forum Infectious Diseases
Volume	7
Issue number	10
DOIs	https://doi.org/10.1093/ofid/ofaa429
State	Published - 1 Oct 2020

Keywords

Acute HIV infection
Fiebig stage
Genetic diversity
HIV

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10.1093/ofid/ofaa429

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title = "Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection",

abstract = "We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.",

keywords = "Acute HIV infection, Fiebig stage, Genetic diversity, HIV",

author = "\{on behalf of the RV254/ SEARCH010 Study Group\} and Hongshuo Song and Meera Bose and Suteeraporn Pinyakorn and Eric Sanders-Buell and O{\textquoteright}Sullivan, \{Anne Marie\} and Daniel Silas and Rapee Trichavaroj and Bessara Nuntapinit and Pham, \{Phuc T.\} and Siriwat Akapirat and Eug{\`e}ne Kroon and \{de Souza\}, Mark and Robert Gramzinski and Michael, \{Nelson L.\} and Robb, \{Merlin L.\} and Sandhya Vasan and Sodsai Tovanabutra and Jintanat Ananworanich",

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doi = "10.1093/ofid/ofaa429",

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AU - on behalf of the RV254/ SEARCH010 Study Group

AU - Song, Hongshuo

AU - Bose, Meera

AU - Pinyakorn, Suteeraporn

AU - Sanders-Buell, Eric

AU - O’Sullivan, Anne Marie

AU - Silas, Daniel

AU - Trichavaroj, Rapee

AU - Nuntapinit, Bessara

AU - Pham, Phuc T.

AU - Akapirat, Siriwat

AU - Kroon, Eugène

AU - de Souza, Mark

AU - Gramzinski, Robert

AU - Michael, Nelson L.

AU - Robb, Merlin L.

AU - Vasan, Sandhya

AU - Tovanabutra, Sodsai

AU - Ananworanich, Jintanat

PY - 2020/10/1

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N2 - We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

AB - We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.

KW - Acute HIV infection

KW - Fiebig stage

KW - Genetic diversity

KW - HIV

UR - https://www.scopus.com/pages/publications/85096713723

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DO - 10.1093/ofid/ofaa429

M3 - Article

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JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

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ER -

Dynamics of human immunodeficiency virus-1 genetic diversification during acute infection

Abstract

Keywords

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