TY - JOUR
T1 - Early detection of dengue infections using cluster sampling around index cases
AU - Beckett, Charmagne G.
AU - Kosasih, Herman
AU - Faisal, Indra
AU - Nurhayati,
AU - Tan, Ratna
AU - Widjaja, Susana
AU - Listiyaningsih, Erlin
AU - Ma'Roef, Chairin
AU - Wuryadi, Suharyono
AU - Bangs, Michael J.
AU - Samsi, Tatang K.
AU - Yuwono, Djoko
AU - Hayes, Curtis G.
AU - Porter, Kevin R.
PY - 2005/6
Y1 - 2005/6
N2 - A two-year study using a cluster investigation method was conducted in West Jakarta, Indonesia to demonstrate the detection of dengue cases prior to onset of clinical illness. The clusters consisted of family members and neighbors of 53 hospitalized dengue index cases. Among 785 adult and child volunteers enrolled, 17 (2.2%) post-enrollment dengue (PED) infections were identified. Eight PED cases were asymptomatic and nine were symptomatic. Symptomatic cases included eight with dengue fever and one with dengue hemorrhagic fever (DHF) (grade II). Among the eight asymptomatic PED cases, viremia was detected in two. Eleven volunteers had acute dengue infections at the time of enrollment. Four of the 11 developed DHF, resulting in a total of five DHF cases detected during the investigation. This study design can serve as a benchmark for future investigations that seek to define early immunologic events following dengue infections that contribute to the development of DHF.
AB - A two-year study using a cluster investigation method was conducted in West Jakarta, Indonesia to demonstrate the detection of dengue cases prior to onset of clinical illness. The clusters consisted of family members and neighbors of 53 hospitalized dengue index cases. Among 785 adult and child volunteers enrolled, 17 (2.2%) post-enrollment dengue (PED) infections were identified. Eight PED cases were asymptomatic and nine were symptomatic. Symptomatic cases included eight with dengue fever and one with dengue hemorrhagic fever (DHF) (grade II). Among the eight asymptomatic PED cases, viremia was detected in two. Eleven volunteers had acute dengue infections at the time of enrollment. Four of the 11 developed DHF, resulting in a total of five DHF cases detected during the investigation. This study design can serve as a benchmark for future investigations that seek to define early immunologic events following dengue infections that contribute to the development of DHF.
UR - http://www.scopus.com/inward/record.url?scp=23844459317&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2005.72.777
DO - 10.4269/ajtmh.2005.72.777
M3 - Article
C2 - 15967759
AN - SCOPUS:23844459317
SN - 0002-9637
VL - 72
SP - 777
EP - 782
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 6
ER -