Early events in the recognition of danger signals after tissue injury

David J. Kaczorowski, Kevin P. Mollen, Rebecca Edmonds, Timothy R. Billiar

Research output: Contribution to journalArticlepeer-review

101 Scopus citations


The systemic inflammatory response observed in the setting of overwhelming infection bears striking similarities to that observed in the setting of severe traumatic injury from a clinical and physiologic standpoint. Recent observations have demonstrated that these disparate clinical entities share common mediators on a molecular level. TLRs, specifically TLR4, and the endogenous molecule high-mobility group box 1 are among the mediators that are known to play a role in inflammation in the setting of sepsis. Evidence is accumulating that demonstrates that these mediators also play a role in the host response to tissue injury. Here, we highlight findings from the 7th World Conference on Trauma, Shock, Inflammation and Sepsis in Munich, Germany, in the context of this growing body of literature.

Original languageEnglish
Pages (from-to)546-552
Number of pages7
JournalJournal of Leukocyte Biology
Issue number3
StatePublished - 1 Mar 2008
Externally publishedYes


  • HMGB1
  • Inflammation
  • Toll-like receptors
  • Trauma


Dive into the research topics of 'Early events in the recognition of danger signals after tissue injury'. Together they form a unique fingerprint.

Cite this