Effect of 1% sodium hyaluronate (Healon®) on a nonregenerating (feline) corneal endothelium

C. F. Bahn, R. Grosserode, D. C. Musch, J. Feder, R. F. Meyer, D. K. MacCallum, J. H. Lillie, N. M. Rich

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15 Scopus citations


A series of experiments were performed to investigate the effect of 1% sodium hyaluronate (Healon®) on the nonregenerating corneal endothelium of the cat. Aqueous humor replacement with 1% sodium hyaluronate resulted in mild, transient elevations of intraocular pressure compared to eyes that were injected with balanced salt solution. Sodium hyaluronate 1% protected the feline endothelium against cell loss incurred by contact with hyaluronate-coated intraocular lenses compared to endothelial contact with lenses that were not coated with sodium hyaluronate. The use of intraoperative 1% sodium hyaluronate, however, did not protect against endothelial cell loss incurred by penetrating keratoplasty or prevent subsequent skin graft-induced corneal homograft rejections. Homograft rejections were milder, however, in some eyes that received grafts coated with 1% sodium hyaluronate. Image analysis of photographs of trypan blue- and alizarin red-stained corneal buttons after trephining, stretching of Descemet's membrane, rubbing against iris-lens preparations, or immediately after penetrating keratoplasty demonstrated that the stretching of the posterior cornea is an important cause of endothelial damage that would not be protected against by a viscoelastic coating.

Original languageEnglish
Pages (from-to)1485-1494
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Issue number10
StatePublished - 1986


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