Effect of donor factors on early graft survival in adult cadaveric renal transplantation

S. John Swanson, Iman O. Hypolite, Lawrence Y.C. Agodoa, D. Scott Batty, Paul B. Hshieh, David Cruess, Allan D. Kirk, Thomas G. Peters, Kevin C. Abbott*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

Previous studies of the effect of donor factors on renal transplant outcomes have not tested the role of recipient body mass index, donor/recipient weight ratios and age matching, and other factors. We analyzed 20309 adult (age 16 or older) recipients having solitary cadaveric renal transplants from adult donors from 1 July 1994 to 30 June 1998 in an historical cohort study (the 2000 United States Renal Data System) of death censored graft loss by the Cox proportional hazards models, which corrected for characteristics thought to affect outcomes. The only independently significant findings in Cox Regression analysis were a high donor/ recipient age ratio (≥ 1.10, e.g. a 55-year-old donor given to a recipient age 50 years or younger, adjusted hazard ratio (AHR) 3.22, 95% confidence interval (CI) 2.36-4.39) and African American donor kidneys (AHR 1.64, 95% CI, 1.24-2.17). African American recipients and older donors were not at independently increased risk of graft failure in this model. Among donor factors, older donor kidneys given to younger recipients and donor African American kidneys were independently associated with graft loss in recipients of cadaver kidneys. The task for the transplant community should be to find the best means for managing all donor organs without discouraging organ donation.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalAmerican Journal of Transplantation
Volume2
Issue number1
DOIs
StatePublished - Jan 2002
Externally publishedYes

Keywords

  • African American donor
  • Body mass index
  • Cadaveric renal transplantation
  • Donor death
  • Donor/recipient weight ratio
  • Graft survival

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